运动调控JAK2/STAT信号通路治疗非酒精性脂肪性肝病机制的研究进展  

Research Progress on the Mechanism of Exercise Regulating JAK2/STAT Signaling Pathway to Treat the Non-Alcoholic Fatty Liver Disease

作　　者：廖春旺 胡雪峰[2] 刘祖辉[1] LIAO Chunwang;HU Xuefeng;LIU Zuhui(College of Sports Science,Fujian Normal University,Fuzhou 350117,China;Fujian Key Laboratory of Developmental and Neuro Biology,College of life Science,Fujian Normal University,Fuzhou 350117,China)

机构地区：[1]福建师范大学体育科学学院,福州350117 [2]福建省发育与神经生物学重点实验室,福建师范大学生命科学学院,福州350117

出　　处：《中国细胞生物学学报》2023年第6期918-928,共11页Chinese Journal of Cell Biology

基　　金：国家自然科学基金面上项目(批准号:81771034)资助的课题。

摘　　要：非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)是现代社会中最常见的一类慢性肝病,包括非酒精性单纯性脂肪肝、非酒精性脂肪性肝炎等,常并发其他代谢病症,严重影响人类身体健康。运动疗法作为一种最经济、便捷且有效的预防和治疗NAFLD的方式,其机制涉及运动对于JAK2/STAT信号通路的调节。JAK2/STAT信号通路是一条与代谢相关的重要通路,通路所涉及的JAK2及部分STAT分子活性水平的降低会导致肝脏细胞出现脂质沉积等不良反应,阻碍肝脏脂质正常代谢,从而引发NAFLD。该文梳理了前人的研究成果,讨论运动通过调节机体内LEP、IGF-1、GH等的分泌水平,直接或间接影响JAK2/STAT信号通路,进而提升脂质代谢水平以改善NAFLD症状,以期为运动干预治疗NAFLD机制探究提供参考。NAFLD(non-alcoholic fatty liver disease)is the most common type of chronic liver disease in modern society,including non-alcoholic simple fatty liver disease and non-alcoholic steatohepatitis,which are often complicated by other metabolic disorders and seriously affect human health.Exercise therapy is the most economical,convenient and effective way to prevent and treat NAFLD,and its mechanism involves the regulation of JAK2/STAT signaling pathway,which is an important metabolism-related pathway.This paper discusses that exercise can directly or indirectly affect the JAK2/STAT signaling pathway by regulating the secretion levels of LEP,IGF-1 and GH in the body,which can enhance the level of lipid metabolism and improve NAFLD,in order to provide a reference for the mechanism of exercise intervention for NAFLD.

关 键 词：非酒精性脂肪性肝病 运动 JAK2 STAT 

分 类 号：R575.5[医药卫生—消化系统]