细菌群体感应信号对宿主免疫调节机制的研究进展  

Research progress on bacterial quorum sensing signal on host immune regulation mechanism

作　　者：邓欣怡 曾振宇 李晓岚[1] Xinyi Deng;Zhenyu Zeng;Xiaolan Li(Hospital of Stomatology,Guanghua School of Stomatology,Sun Yat-sen University,Guangdong Provincial Key Laboratory of Stomatology,Guangzhou 510055,China)

机构地区：[1]中山大学附属口腔医院,光华口腔医学院,广东省口腔医学重点实验室,广州510055

出　　处：《中华口腔医学研究杂志（电子版）》2023年第2期140-147,共8页Chinese Journal of Stomatological Research(Electronic Edition)

基　　金：2022年国家级大学生创新训练计划项目(202210762);2023年大学生创新训练计划项目(202310778)。

摘　　要：群体感应(QS)是细菌通过感知特定群体感应信号分子(QSSM)的浓度阈值,以调节菌群基因表达,改变细菌及菌群行为的系统。这种调节机制在细菌与宿主的相互作用中也发挥重要作用。细菌释放QSSM被宿主感知,启动相关信号通路,激活或抑制基因表达。目前研究显示,宿主细胞的细胞膜、细胞质、细胞器和细胞核等参与QSSM刺激的多种信号通路,介导宿主的相关免疫应答。本文将对QSSM的分类、作用宿主的途径以及作用结果的研究进展进行综述。Quorum sensing(QS)is a system that bacteria can regulate the gene expression and change the behavior of microbiome by sensing the concentration threshold of specific quorum sensing signal molecules(QSSMs).This regulatory mechanism also plays an important role in the interaction between bacteria and host.The release of QSSMs by bacteria is sensed by the host,which initiates relevant signaling pathways to activate or inhibit gene expression.Current researches have shown that various structures of the host cells,including the cell membrane,cytoplasm,organelles and nucleus are involved in multiple signaling pathways irritated by QSSMs,and mediate relevant host immune responses.In this article,the classification of QSSMs,the research progress of the pathway and effects on hosts were reviewed.

关 键 词：细菌 宿主 群体感应 免疫调节 

分 类 号：R78[医药卫生—口腔医学]