MALAT1、HOTAIR、NEAT1调控结直肠癌的研究进展  

Research progress in the regulation of colorectal cancer by MALAT1,HOTAIR,and NEAT1

作　　者：李瑞娜 徐辉 李宁宁(综述) 高小玲(审校) LI Ruina;XU Hui;LI Ningning;GAO Xiaoling(Department of Anesthesiology,Gansu Provincial Hospital,Lanzhou,Gansu 730000,China;Department of Clinical Laboratory,Hainan General Hospital,Haikou,Hainan 570100,China;Department of Paediatrics,Lanzhou Maternal and Child Health Hospital,Lanzhou,Gansu 730000,China)

机构地区：[1]甘肃省人民医院麻醉科,甘肃兰州730000 [2]海南省人民医院检验科,海南海口570100 [3]兰州市妇幼保健院儿科,甘肃兰州730000

出　　处：《国际检验医学杂志》2023年第17期2149-2154,共6页International Journal of Laboratory Medicine

基　　金：国家自然科学基金项目(81830372,8226080137);海南省卫生行业科研计划项目(ZDYF2022SHFZ055)。

摘　　要：结直肠癌作为一种遗传性疾病,其发病机制涉及多个基因。长链非编码RNA(lncRNA)在肿瘤发生过程中起着重要的调节作用,对肿瘤的发展有重要影响。该文概述了lncRNA在结直肠癌中作为竞争性内源性RNA如何发挥其功能以及它们的表达是如何被调节,并重点介绍了以下lncRNA:HOTAIR、MALAT1、NEAT1在结直肠癌预后与肿瘤进展、侵袭、转移、细胞凋亡、放射抵抗等方面的作用机制,并阐明其作为治疗靶点的潜在作用。Colorectal cancer,as a genetic disease,involves multiple genes in its pathogenesis.Long non-coding RNAs(lncRNA)play an important regulatory role in tumorigenesis and have a significant impact on tumor progression.In this review,how lncRNA function as competing endogenous RNAs in colorectal cancer and how their expression is regulated are outlined,and the mechanisms of action of the following lncRNA:HOX antisense intergenic RNA(HOTAIR),metastasis-associated lung adenocarcinoma transcript 1(MALAT1),nuclear enriched transcript 1(NEAT1)in colorectal cancer prognosis and tumor progression,invasion,metastasis,apoptosis,and radioresistance are highlighted,and their potential roles as therapeutic targets are elucidated.

关 键 词：结直肠癌 长链非编码RNA 竞争性内源性RNA 肺腺癌转移相关转录因子1 HOX反义基因间RNA 核富集转录本1 

分 类 号：R735.35[医药卫生—肿瘤]