Ⅰ型酪蛋白激酶Hrr25的生物学功能和作用机制  

Biological Functions and Mechanism of Casein KinaseⅠHrr25

作　　者：姜文艳 张文婷[1] 王娟[1] JIANG Wen-Yan;ZHANG Wen-Ting;WANG Juan(Department of Biotechnology,Faculty of Environment and Life,Beijing University of Technology,Beijing 100124,China)

机构地区：[1]北京工业大学环境与生命学部生物技术系,北京100124

出　　处：《中国生物化学与分子生物学报》2023年第8期1079-1086,共8页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家自然科学基金项目(No.31970044)资助。

摘　　要：Hrr25是酿酒酵母中Ⅰ型酪蛋白激酶家族成员,具有丝氨酸/苏氨酸蛋白激酶活性。其可以通过磷酸化多种蛋白质来发挥作用。Hrr25的底物蛋白质包括自噬相关蛋白、COPⅡ(coat protein complexes Ⅱ)囊泡衣被蛋白Sec24和Sec23、真核翻译起始因子6、γ-微管蛋白Tub4、延长器复合蛋白1等。另外Hrr25还可以与减数分裂重组蛋白Rec8、核孔蛋白Nup53、转录调节因子Crz1、转录激活因子Haa1等相互作用。Hrr25的多种相互作用蛋白质使其在自噬、囊泡运输、微管组装、减数分裂、有丝分裂、DNA修复、核糖体生物发生和弱有机酸胁迫途径等多种生物过程发挥作用。为了更好地了解Hrr25在各个生物过程中的作用机制以及各个生物过程之间的联系,本文总结了Hrr25的生物学功能及其作用机制,并概述其研究的潜在意义,为Hrr25的进一步研究提供理论依据。Hrr25 is a member of the casein kinase 1 family in Saccharomyces cerevisiae and has serine/threonine protein kinase activity.It can function by phosphorylating a variety of proteins.The substrate proteins of Hrr25 include autophagy related proteins,COPII(coat protein complexes II)vesicle coat pro-teins Sec24 and Sec23,eukaryotic translation initiation factor 6,γ-Tubulin tub4,and extender complex protein 1,etc.In addition,Hrr25 can also interact with meiotic recombinant protein Rec8,Nucleoporin Nup53,transcription regulator Crz1,and transcription activator Haa1,etc.A variety of interacting pro-teins of Hrr25 enable it to play a role in autophagy,vesicular transport,microtubule assembly,meiosis,mitosis,DNA repair,ribosomal biogenesis,weak organic acid stress and other biological processes.In order to better understand the action mechanism of Hrr25 in various biological processes and the relation-ship between various biological processes,this paper summarizes the biological functions and action mechanism of Hrr25,and the potential significance of its research,so as to provide a theoretical basis for the further research of Hrr25.

关 键 词：Hrr25 酿酒酵母 细胞分裂 囊泡运输 

分 类 号：Q25[生物学—细胞生物学]