山西省女性人乳头瘤病毒感染现状分析  

Analysis of the current situation of human papillomavirus infection in females in Shanxi Province

作　　者：秦毓 杨苗 畅锴 王舒宁 Qin Yu;Yang Miao;Chang Kai;Wang Shuning(Taiyuan Jinyu Clinical Laboratory Co.,Ltd,Taiyuan Shanxi 030032,China)

机构地区：[1]太原金域临床检验所有限公司,山西太原030032

出　　处：《中华临床实验室管理电子杂志》2023年第2期105-108,共4页Chinese Journal of Clinical Laboratory Management(Electronic Edition）

摘　　要：目的高危型人乳头瘤病毒(HPV)持续感染是宫颈癌的主要病因,因此HPV分型检测对于宫颈癌的早期筛查有重要意义。本文主要对山西省女性HPV不同型别的感染情况进行具体分析。方法选取2021年10月至12月在山西太原金域临床检验所有限公司进行HPV筛查的48661例样本,通过反向点杂交方法进行检测并对结果进行统计分析。结果宫颈脱落细胞样本中HPV阳性感染率为20.57%,其中高危型HPV感染率为17.73%,低危型HPV感染率为5.22%。HPV感染者中单一型别感染人数多于多型别合并感染者,其中感染单一高危型居多(58.67%),其次为多型别合并感染者中感染混合高危型(15.94%)。23种HPV基因型中高危型HPV易感染的分别是52型、16型、53型、58型、51型、56型;低危型HPV易感染的分别是81型、42型、43型。分析5组年龄段感染情况,发现55岁以上女性感染率最高(32.63%)。结论山西省55岁以上女性HPV感染率较高,需要加强宫颈癌与HPV关系的宣传,定期进行HPV筛查,早发现宫颈癌癌前病变并加以治疗,有效预防宫颈癌的发生。Objective Persistent infection of high-risk human papillomavirus is the main cause of cervical cancer,so HPV typing test has a defensive effect on the early screening of cervical cancer.This paper mainly analyzes the infection situation of different types of HPV in women in Shanxi Province.MethodsA total of 48661 samples of HPV screening at Taiyuan Jinyu Clinical Laboratory Co.,Ltd were selected from October to December 2021 and statistically analyzed by reverse point hybridization.ResultsThe rate of HPV-positive infection in 48661 cervical detached cell samples was 20.57%,including 17.73%for high-risk HPV infection and 5.22%for low-risk HPV infection.The number of HPV infected persons with single type was more than that of multi-type co-infected patients,among which the single high-risk type was the majority(58.67%),followed by the mixed high-risk types(15.94%).Among the 23 HPV genotypes,high-risk HPV types are susceptible to infection:HPV52,16,53,58,51 and 56;low-risk HPV types are susceptible to infection:81,42,and 43.Analysis of the infection in 5 age groups showed that the infection rate of women over 55 years old was the highest(32.63%).Conclusions From the above data,it can be found that the HPV infection rate of women over the age of 55 in Shanxi Province is relatively high.It is necessary to strengthen the publicity of cervical cancer and the relationship between HPV,regular HPV screening,and early detection and treatment of cervical precancerous lesions,so as to effectively prevent the occurrence of cervical cancer.

关 键 词：人乳头瘤病毒 高危型HPV 低危型HPV 多分型合并感染 

分 类 号：R737.33[医药卫生—肿瘤]