吡咯啉-5-羧酸还原酶1对恶性肿瘤生物学行为的影响及分子机制研究进展  

Research progress on the effect of PYCR1 on the biological behavior of malignant tumors and its molecular mechanism

作　　者：尤程程[1,2] 张小玲 黄益玲[1,2] YOU Chengcheng;ZHANG Xiaoling;HUANG Yiling(Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy,China Three Gorges University,Hubei Yichang 443002,China;Department of Pathology,College of Basic Medical Science,China Three Gorges University,Hubei Yichang 443002,China;Yichang Akeman Pathology and Diagnostics Center,Hubei Yichang 443002,China)

机构地区：[1]肿瘤微环境与免疫治疗湖北省重点实验室(三峡大学),湖北宜昌443002 [2]三峡大学基础医学院病理系,湖北宜昌443002 [3]宜昌阿克曼病理诊断中心,湖北宜昌443002

出　　处：《现代肿瘤医学》2023年第17期3319-3324,共6页Journal of Modern Oncology

基　　金：国家自然科学基金面上项目(编号:81374024);湖北省教育厅科研计划项目(编号:B2022033);湖北省中医药管理局中医药指导性项目(编号:ZY2023F145);三峡大学基础与临床病理学研究中心开放基金(编号:RHKFBL2022-01)。

摘　　要：吡咯啉-5-羧酸还原酶1(pyrroline-5-carboxylate reductase 1,PYCR1)是脯氨酸合成的关键酶,近年来研究发现PYCR1基因在多种恶性肿瘤中高表达,影响了肿瘤的发生发展,有望成为新的有潜力的肿瘤标志物和治疗靶点。本文概述了PYCR1基因的结构和分布,并重点介绍其在恶性肿瘤细胞增殖、侵袭、耐药等生物学行为中的作用机制,最后讨论了PYCR1基因相关的调控分子和抑制剂。Pyrroline-5-carboxylate reductase 1(PYCR1)is a key enzyme in proline synthesis.Recent studies have found that PYCR1 is highly expressed in malignant tumors and affects the malignant biological behavior of tumors.It is expected to be a new potential tumor marker and therapeutic target.This article summarized the structure and distribution of PYCR1 gene,and the mechanism of PYCR1 gene in proliferation,invasion,drug resistance of malignant tumor cells.Finally,we discussed the regulatory molecules and inhibitors related to PYCR1 gene.

关 键 词：PYCR1基因 耐药性 肿瘤 

分 类 号：R730.2[医药卫生—肿瘤]