五羟色胺与癌症关系的研究进展  

Advances in research on the relationship between 5-hydroxytryptamine and cancer

作　　者：黄淑婷 吴晓雪 梅永 李清海 宋梅 何伟玲[3,4] HUANG Shuting;WU Xiaoxue;MEI Yong;LI Qinghai;SONG Mei;HE Weiling(College of Public Health,Sun Yat-sen University,Guangdong Guangzhou 510080,China;Institute of Precision Medicine,the First Affiliated Hospital,Sun Yat-sen University,Guangdong Guangzhou 510000,China;Department of Gastrointestinal Surgery,the First Affiliated Hospital,Sun Yat-sen University,Guangdong Guangzhou 510080,China;Department of Gastrointestinal Surgery,Xiang'an Hospital of Xiamen University,Fujian Xiamen 361000,China)

机构地区：[1]中山大学公共卫生学院,广东广州510080 [2]中山大学附属第一医院精准医学研究院,广东广州510000 [3]中山大学附属第一医院胃肠外科,广东广州510080 [4]厦门大学附属翔安医院胃肠外科,福建厦门361000

出　　处：《现代肿瘤医学》2023年第18期3497-3501,共5页Journal of Modern Oncology

基　　金：国家重点研发计划“前沿生物技术”专项(编号:2022YFC3401000);国家自然科学基金优秀青年项目(编号:82022037);广东省基础与应用基础研究基金省企联合基金重点项目(编号:2021B1515230009);广东省重点领域研发计划(编号:2020B0101030006)。

摘　　要：五羟色胺(5-hydroxytryptamine,5-HT)作为中枢神经系统中的神经递质和胃肠道中运动调节因子所发挥的作用已经明确,其在各种癌症发生中的作用正在研究中。5-HT可以通过不同的受体和机制激活PI3K/AKT通路、MAPK通路、JAK/STAT通路、Wnt通路等,促进细胞增殖和迁移,介导抗肿瘤免疫应答,其代谢通路中的多种酶在多种肿瘤中高表达,是肿瘤治疗的潜在靶点。近年来,在多种肿瘤中都发现了5-HT的代谢紊乱,包括结直肠癌、肝癌、胰腺癌、卵巢癌、前列腺癌、乳腺癌等,因此针对5-HT代谢的研究在肿瘤治疗中具有重要意义。本综述系统总结了5-HT与癌症的相关关系及研究进展,阐明了5-HT作为潜在新的癌症治疗靶点的科学依据,这为开发靶向5-HT代谢途径的酶、代谢物或受体的药物提供了新思路。The role of 5-hydroxytryptamine(5-HT)as a neurotransmitter in the central nervous system and a motor regulator in the gastrointestinal tract has been well established,and its role in the occurrence of various cancers is under investigation.5-HT can activate the PI3K/AKT pathway,MAPK pathway,JAK/STAT pathway,Wnt pathway through different receptors and mechanisms,promote cell proliferation and migration,and mediate anti-tumor immune responses.A variety of enzymes in its metabolic pathways are highly expressed in a variety of tumors,which is a potential target for tumor treatment.In recent years,metabolic disorders of 5-HT have been found in a variety of tumors,including colorectal cancer,liver cancer,pancreatic cancer,ovarian cancer,prostate cancer,breast cancer,etc.Therefore,the research on 5-HT metabolism is of great significance in tumor treatment.This review systematically summarizes the relationship between 5-HT and cancer and the research progress,and elucidates the scientific basis for 5-HT as a potential new cancer treatment target,which provides new ideas for the development of drugs targeting the enzymes,metabolites or receptors of 5-HT metabolic pathway.

关 键 词：五羟色胺 五羟色胺受体 癌症治疗靶点 

分 类 号：R730.5[医药卫生—肿瘤]