牙囊在牙萌出骨重塑的调控作用及机制研究进展  

Research progress of the regulatory mechanisms of dental follicle in bone remodeling during tooth eruption

作　　者：姜震 韩雪 蒋备战[1] JIANG Zhen;HAN Xue;JIANG Beizhan(Department of Pediatric Dentistry,Stomatological Hospital and Dental School of Tongji University,Shanghai Engineering Research Center of Tooth Restoration and Regeneration,Shanghai 200072,China)

机构地区：[1]同济大学口腔医学院·附属口腔医院儿童口腔科上海牙组织修复与再生工程技术研究中心,上海200072

出　　处：《口腔医学》2023年第8期752-756,共5页Stomatology

基　　金：国家自然科学基金(82000995);上海市卫生健康委员会科研项目(202140357)。

摘　　要：牙萌出是一个复杂的生理过程,涉及牙槽骨的吸收和形成。研究表明,牙囊通过调节牙齿周围骨组织重塑,在牙萌出中发挥关键作用。牙囊分泌多种趋化因子招募单核细胞,并通过RANKL/RANK/OPG轴促进破骨细胞分化成熟,导致冠方骨质吸收形成萌出道;同时牙囊内富含具有成骨分化潜能的牙囊细胞,在TGF-β/BMP和Wnt等信号通路以及表观遗传的调控下诱导根方牙槽骨形成,为萌出提供动力。近年来,有关牙萌出骨重塑机制研究取得了新进展,本文就牙萌出过程中牙囊参与调控骨重塑的细胞及分子机制作一综述。Tooth eruption undergoes a series of sophisticated physiological procedures that involve the formation and resorption of alveolar bone.Previous studies indicated that dental follicle(DF)plays a key role in tooth eruption by modulating bone remodeling around the tooth.It secretes multiple chemokines to recruit monocytes and facilitate the differentiation and maturation of osteoclasts via RANKL/RANK/OPG axis,eventually leading to the resorption of the coronal alveolar bone to form eruptive pathway.Simultaneously,dental follicle is enriched with dental follicle cells,whose osteogenic activity are subject to TGF⁃β/BMP and WNT signaling pathway as well as epigenetic regulation,which in turn promotes the formation of basal alveolar bone and provides motive force for tooth eruption.In recent years,studieson bone remodeling mechanisms of tooth eruption have made further progress,and this review elaborates the cel⁃lular and molecular mechanisms involved in bone remodeling by dental follicle during tooth eruption.

关 键 词：牙囊 牙萌出 骨重塑 破骨细胞 成骨分化 

分 类 号：R781[医药卫生—口腔医学]