长链非编码RNA人肺腺癌转移相关转录本1在结直肠癌中的研究进展  

Research progress of long non-coding RNA lung adenocarcinoma metastasis-associated transcript 1 in colorectal cancer

作　　者：范乘风 杨劲松[1] FAN Chengfeng;YANG Jinsong(Department of Medical Oncology,Nanjing Hospital Affiliated to Nanjing Medical University,Nanjing,Jiangsu,210006)

机构地区：[1]南京医科大学附属南京医院肿瘤内科,江苏南京210006

出　　处：《实用临床医药杂志》2023年第14期115-120,共6页Journal of Clinical Medicine in Practice

基　　金：国家自然科学基金资助项目(81673030)。

摘　　要：长链非编码RNA(lncRNA)是一种长度大于200个核苷酸,且不具备蛋白质编码能力的RNA,其在癌症的发生发展中起重要作用。lncRNAs涉及转录、转录后修饰、染色质修饰以及表观遗传学修饰等多种基因调控过程,其是细胞周期、细胞分化发育、细胞多能性等生物过程中最重要的参与者。肺腺癌转移相关转录本1(MALAT1)作为被广泛研究的lncRNAs之一,在结直肠癌中呈高表达。研究已表明,MALAT1及其单核苷酸多态性(SNPs)在结直肠癌的发生发展中起重要作用,可成为结直肠癌临床诊断、治疗与预后的靶标。本文就lncRNA MALAT1在结直肠癌中的相关研究现状进行综述。Long non-coding RNA(lncRNA)is a kind of RNA with a length of more than 200 nucleotides,which does not have the ability to encode proteins,and plays an important role in the development of cancer.LncRNAs are involved in various gene regulatory processes such as transcription,post-transcriptional modification,chromatin modification and epigenetic modification,and are the most important participants in biological processes such as cell cycle,cell differentiation and development,and cell pluripotency.As one of the most widely studied lncRNAs,metastasis-associated lung adenocarcinoma transcript-1(MALAT1)is highly expressed in colorectal cancer.Studies have shown that MALAT1 and its single nucleotide polymorphisms(SNPs)play important roles in the occurrence and development of colorectal cancer,and can be used as targets for clinical diagnosis,treatment and prognosis of colorectal cancer.This article reviewed the current status of research on lncRNA MALAT1 in colorectal cancer.

关 键 词：长链非编码RNA 肺腺癌转移相关转录本1 单核苷酸多态性 结直肠癌 治疗靶点 

分 类 号：R735.3[医药卫生—肿瘤] Q81[医药卫生—临床医学]