贵州省非职业接触汞健康人群血和尿汞水平及其参考值范围  

Study on the reference range of blood and urine mercury among non-occupational healthy population in Guizhou

作　　者：李佐祥 刘梅 侯腾 吴锡红 陈博 李玲 张莎 朱艺 程旭旭 尚玉蓉 LI Zuoxiang;LIU Mei;HOU Teng;WU Xihong;CHEN Bo;LI Ling;ZHANG Sha;ZHU Yi;CHENG Xuxu;SHANG Yurong(Department of Clinical Laboratory,No.3 People's Hospital of Guizhou Province,Guiyang 550008,Guizhou,China;Occupational Medicine,No.3 People's Hospital of Guizhou Province,Guiyang 550008,Guizhou,China;Department of Medical Technology,Guiyang Kangyang Vocational University,Guiyang 550081,Guizhou,China)

机构地区：[1]贵州省第三人民医院检验科,贵州贵阳550008 [2]贵州省第三人民医院职业病科,贵州贵阳550008 [3]贵阳康养职业大学医学技术系,贵州贵阳550081

出　　处：《贵州医科大学学报》2023年第8期908-913,共6页Journal of Guizhou Medical University

基　　金：贵州省卫生健康委科学技术基金(gzwjkj2019-1-195)。

摘　　要：目的探讨贵州省非职业接触汞(Hg)人群血和尿Hg水平及其参考值范围。方法选取非职业接触Hg健康体检者1080人为研究对象,将备检人群根据性别、年龄段及居住地区分组;采集体检日空腹静脉全血及1次性随机中段尿,采用原子荧光光谱法测定血Hg水平,采用碱性氯化亚锡还原-冷原子吸收法检测尿Hg水平、并用肌酐进行尿Hg校准,采用百分位数法建立血和尿Hg的参考值范围。结果贵州地区非职业接触Hg健康人群血Hg、尿Hg的参考值范围为0.08~10.79μg/L和0.06~3.47μg/gCr;男性非职业接触Hg健康人群血Hg高于女性(P<0.05),21~30岁组非职业接触Hg健康人群血Hg水平高于其他年龄组(P<0.05);毕节地区非职业接触Hg健康人群血Hg高于其他地区(P<0.05),41~50岁组非职业接触Hg健康人群尿Hg高于其他年龄组(P<0.05);黔东南地区非职业接触Hg健康人群尿Hg高于其他地区(P<0.05)。结论初步建立了贵州地区非职业接触Hg健康人群血Hg、尿Hg的参考值范围。Objective To investigate the reference range of blood and urine mercury(Hg)levels in healthy non-occupationally exposed individuals in Guizhou province.Methods A total of 1080 healthy individuals without occupational exposure to Hg were selected as the study subjects.They were grouped by gender,age groups and residential areas.Fasting venous blood and one-time random mid-stream urine sample were collected on the day of the health check-up.The blood Hg level was determined using atomic fluorescence spectrometry,and the urine Hg level was measured using alkaline stannous chloride reduction-cold atomic absorption spectrometry with urine creatinine calibration.The reference values of blood and urine Hg were established using the percentile method.Results The reference range of blood Hg and urine Hg in non-occupationally exposed healthy individuals in Guizhou were 0.08-10.79μg/L and 0.06-3.47μg/gCr,respectively.The blood Hg level in male non-occupationally exposed healthy individuals was higher than that of females(P<0.05),and the blood Hg level in the 21-30 age group was higher than that of other age groups(P<0.05).The blood Hg level in non-occupationally exposed healthy individuals living in Bijie was higher than that in other areas(P<0.05),and the urine Hg level in the 41-50 age group was higher than that in other age groups(P<0.05).The urine Hg level in non-occupationally exposed healthy individuals in southeastern Guizhou was higher than that in other areas(P<0.05).Conclusion The reference range of blood and urine Hg levels in non-occupationally exposed healthy individuals in Guizhou have been preliminarily established.

关 键 词：贵州地区 非职业人群 汞 血汞 尿汞 参考区间 

分 类 号：R5755[医药卫生—消化系统]