大肠癌急性肠梗阻导管植入后患者不良反应及疗效分析  

Analysis of adverse events and therapeutic effect in colorectal cancer patients with acute intestinal obstruction after catheter implantation

作　　者：王海婷 WANG Haiting(Tumor Nutrition and Metabolism Center,Beijing Shijitan Hospital,CMU,Beijing 100000,China)

机构地区：[1]首都医科大学附属北京世纪坛医院肿瘤营养与代谢中心,北京市100000

出　　处：《河北医药》2023年第17期2662-2664,2668,共4页Hebei Medical Journal

摘　　要：目的观察大肠癌急性肠梗阻患者临床治疗过程中肠梗阻导管植入的疗效与安全性。方法选择2019年5月至2022年5月手术治疗的大肠癌急性肠梗阻患者54例,按照对患者采取的治疗方式分为内镜组(予以内镜支架植入治疗)和导管组(予以肠梗阻导管植入治疗),每组27例。观察2组肠梗阻缓解优良率、治疗后不良反应,记录2组治疗相关指标,治疗前后比较2组腹围、KPS评分、白介素-8(IL-8)与降钙素原(PCT)水平。结果导管组患者肠梗阻缓解优良率高于内镜组(P<0.05);导管组手术时间、腹部胀痛缓解时间、拔管时间、排气时间、总住院时间短于内镜组(P<0.05);导管组腹围明显小于内镜组,KPS卡氏评分高于内镜组(P<0.05);导管组IL-8、PCT水平低于内镜组(P<0.05);导管组总不良反应低于内镜组(P<0.05)。结论肠梗阻导管植入治疗效果、安全性较内镜支架植入更佳,可显著缩小腹围,加速症状消退,下调IL-8、PCT水平,促进功能恢复。Objective To observe the efficacy and safety of intestinal catheter implantation on colorectal cancer(CRC)patients with acute intestinal obstruction.Methods A total of 54 CRC patients with acute intestinal obstruction who underwent surgery in our hospital from May 2019 to May 2022 were selected as clinical subjects.According to the treatment methods,they were divided into endoscopic group(treated with endoscopic stent implantation)and catheter group(treated with intestinal catheter implantation),with 27 cases in each group.The excellent and good rate of intestinal obstruction relief,adverse events after treatment,and relevant indicators in the two groups were recorded.The abdominal circumference,the Karnofsky Performance Status(KPS)score,interleukin-8(IL-8)and procalcitonin(PCT)levels before and after treatment in both groups were compared.Results The superior rate of intestinal obstruction relief in the catheter group was significantly higher than that in the endoscope group(P<0.05).The operation time,abdominal pain relief time,extubation time,exhaust time and length of stay in the catheter group were significantly shorter than those in the endoscope group(P<0.05).The abdominal circumference in the catheter group was significantly smaller than that in the endoscopic group,and the KPS score was significantly higher(P<0.05).IL-8 and PCT levels in the catheter group were significantly lower than those in the endoscope group(P<0.05).The incidence of adverse reactions after treatment in the catheter group was significantly lower than that in the endoscopic group(P<0.05).Conclusion The therapeutic efficacy and safety of intestinal catheter implantation are better than those of endoscopic stent implantation for CRC patients with intestinal obstruction,which can significantly reduce the abdominal circumference,accelerate the resolution of symptoms,downregulate IL-8 and PCT,and promote the function recovery.

关 键 词：肠梗阻导管植入 大肠癌 急性肠梗阻 炎性因子 不良反应 

分 类 号：R574.6[医药卫生—消化系统]