帕金森病患者认知障碍的血管性影响因素  

Vascular Factors Affecting Cognitive Disorder in Patients with Parkinson Disease

作　　者：任雅芳 王春慧 禹萌 范文斐 刘冰[1] 郑世茹 张淑玲[1] 付胜奇 REN Yafang;WANG Chunhui;YU Meng;FAN Wenfei;LIU Bing;ZHENG Shiru;ZHANG Shuling;FU Shengqi(First Department of Neurology,the Fifth Clinical Medical College of Henan University of Traditional Chinese Medicine/Zhengzhou People’s Hospital,Zhengzhou 450000,China)

机构地区：[1]河南中医药大学第五临床医学院/郑州人民医院神经内一科,河南郑州450000

出　　处：《河南医学研究》2023年第17期3110-3113,共4页Henan Medical Research

基　　金：河南省医学科技攻关计划项目(SB201903029)。

摘　　要：目的了解帕金森病患者认知障碍的发生情况,并对血管性影响因素进行分析。方法将2020年1月至2022年12月就诊于河南中医药大学第五临床医学院的134例帕金森病患者作为研究对象,均通过蒙特利尔认知评价量表(MoCA)评估认知障碍发生情况,记录年龄、性别、受教育程度、病程等一般资料以及吸烟、饮酒、合并高血压、冠心病、高脂血症、血清同型半胱氨酸(Hcy)、尿酸和胱抑素C等血管性因素指标。logistic回归分析确定帕金森病认知障碍发生的血管性因素。结果经MoCA评估,将研究对象分为认知障碍组(73例,占54.48%)和无认知障碍组(61例,占45.52%)。认知障碍组患者受教育程度初中及以下、合并高脂血症占比高于无认知障碍组,年龄、病程、血清Hcy和胱抑素C水平高于无认知障碍组,而血清尿酸水平低于无认知障碍组(P<0.05)。logistic回归分析结果可见,病程、合并高脂血症、血清Hcy和血清胱抑素C是帕金森病认知障碍发生的独立危险因素(P<0.05)。结论帕金森病患者合并高脂血症、血清Hcy、血清胱抑素C等血管性因素和病程存均为发生认知障碍的独立危险因素。Objective To understand the incidence of cognitive disorder in patients with Parkinson disease and analyze the vascular factors.Methods A total of 134 patients with Parkinson disease admitted to the Fifth Clinical Medical College of Henan University of Traditional Chinese Medicine from January 2020 to December 2022 were studied.Montreal cognitive assessment(MoCA)was used to assess the occurrence of cognitive disorder.General personal information of age,gender,education level,disease duration were recorded,as well as vascular factors of smoking,alcohol consumption,hypertension,coronary heart disease,hyperlipidemia,serum homocysteine(Hcy),uric acid and cystatin C were recorded.The vascular factors of Parkinson cognitive disorder were determined by logistic regression analysis.Results The subjects were divided into cognitive disorder group(73 cases,accounting for 54.48%)and non-cognitive disorder group(61 cases,accounting for 45.52%)according to the MoCA test.The percentages of junior high school education or below and hyperlipidemia of cognitive disorder group were higher than those of non-cognitive disorder group,the age,disease course,serum Hcy and cystatin C of cognitive disorder group were higher than those of non-cognitive disorder group,but the uric acid was lower than that in non-cognitive disorder group(P<0.05).Logistic regression analysis showed that the disease duration,hyperlipidemia,serum Hcy and serum cystatin C were independent risk factors for cognitive disorder in Parkinson disease(P<0.05).Conclusion Vascular factors such as hyperlipidemia,serum Hcy,serum cystatin C and disease duration are independent risk factors for cognitive disorder in Parkinson disease patients.

关 键 词：帕金森病 认知障碍 血管性因素 LOGISTIC回归分析 

分 类 号：R742.5[医药卫生—神经病学与精神病学]