对羟基苯甲酸酯类防腐剂的环境和人体暴露研究进展  

Research progress in the study of environmental and human exposure to paraben preservatives

作　　者：韩林学 张续[1] 邱天[1] 胡小键[1] 朱英[1] 林潇 HAN Linxue;ZHANG Xu;QIU Tian;HU Xiaojian;ZHU Ying;LIN Xiao(China CDC Key Laboratory of Environment and Population Health,National Institute of Environmental Health,Chinese Center for Disease Control and Prevention,Beijing,100021,China)

机构地区：[1]中国疾病预防控制中心环境与人群健康重点实验室,中国疾病预防控制中心环境与健康相关产品安全所,北京100021

出　　处：《环境化学》2023年第8期2563-2575,共13页Environmental Chemistry

基　　金：环境化学与生态毒理学国家重点实验室开放基金(KF2020-17)资助。

摘　　要：对羟基苯甲酸酯(parabens,PBs)作为一类防腐剂,因其具有独特的理化性质而被广泛应用于食品、药品和个人护理品中.但随着科学技术的发展和研究的不断深入,PBs被证明在一定程度上具有与持久性有机污染物相类似的“持久性、生物富集性和生物毒性”,是潜在的内分泌干扰物.近年来此类防腐剂已经在世界范围内的环境介质和人体样本中被广泛检出,且检出浓度呈逐年上升趋势,引发国内外高度关注.本文分别从环境外暴露和人体内暴露两个方面,对国内外最新的PBs暴露相关研究成果进行归纳和总结,为开展PBs人体暴露和健康风险评估研究提供参考及思路.Parabens(PBs)are widely used as preservatives in food,pharmaceuticals and personal care products because of their unique physicochemical properties.However,with the advancement of research and technology,PBs have been proved to be“persist,bioaccumulative and biotoxic”,which is similar to persistent organic pollutants(POPs),as well as been identified as potential endocrine disrupting chemicals.In recent years,PBs have been widely detected in environmental matrices and human samples worldwide.The detection of PBs has been increasing over the years,which has aroused great concern both domestically and internationally.This review therefore focuses on the latest global research findings in the assessment of human exposure to PBs,both externally and internally to provide ideas for further research on human exposure and health risk assessment of PBs.

关 键 词：对羟基苯甲酸酯 防腐剂 环境外暴露 人体内暴露 

分 类 号：X503.1[环境科学与工程—环境工程]