肠上皮发育通路在炎症性肠病中的研究进展  

Progress of the intestinal epithelial development pathways in inflammatory bowel disease

作　　者：张琨 许玲芬[1] Zhang Kun;Xu Lingfen(Department of Pediatrics Gastroenterology,Shengjing Hospital,China Medical University,Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院小儿消化内科,沈阳110004

出　　处：《中华炎性肠病杂志（中英文）》2023年第3期301-306,共6页Chinese Journal of Inflammatory Bowel Diseases

基　　金：辽宁省自然科学基金(2019⁃MS⁃372);辽宁省科技厅民生科技计划联合计划(2021JH2/10300094)。

摘　　要：炎症性肠病(IBD)是一类病因尚不清楚的反复发作的肠道慢性非特异性炎性疾病。IBD患者的病理特征表现为肠上皮屏障功能障碍与隐窝破坏。越来越多的证据证明上皮屏障完整性在肠道稳态中的重要作用。IBD患者屏障功能障碍早于临床症状的出现,同时屏障的破坏加速了疾病进程。本文主要从肠上皮的构成、发育以及与发育相关的信号通路在IBD发病机制中的研究进展来综述肠上皮屏障与IBD的关系,以期为IBD的治疗提供新思路。Inflammatory bowel disease(IBD)is a type of recurrent chronic non⁃specific inflammatory disease of the intestinal tract with unclear etiology.The pathological features of IBD patients are the dysfunction of intestinal epithelial barrier and destruction of crypt.More and more evidences show the importance of epithelial barrier integrity in intestinal homeostasis.Barrier dysfunction in IBD patients occurs earlier than clinical symptoms,and accelerates the progression of the disease.This article mainly reviews the relationship between intestinal epithelial barrier and IBD from the composition and development of intestinal epithelium,and the progress of developmental signaling pathways in the pathogenesis of IBD,in order to provide the new ideas for the treatment of IBD.

关 键 词：炎症性肠病 信号转导 肠上皮屏障 发育 

分 类 号：R574[医药卫生—消化系统]