Changes of retinal vessel density in low to moderate myopic eyes with orthokeratology evaluated by optical coherence tomography angiography  

作　　者：Jia-Hui Shi Yi-Ping Zhao Gang Liu Xin-Yi Huang Li-Li Lang Wan-Cheng Jia Ji-Li Chen 

机构地区：[1]Medical College of Anhui University of Science and Technology,Huainan 232000,Anhui Province,China [2]South Hospital of the Sixth People’s Hospital,Shanghai 201400,China [3]Shibei Hospital,Shanghai 200435,China

出　　处：《International Journal of Ophthalmology(English edition)》2023年第9期1512-1520,共9页国际眼科杂志（英文版）

基　　金：Supported by Medical Research Fund of Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Medical Group.

摘　　要：AIM:To explore the effect of orthokeratology(OK)fitting on retinal vessel density in low to moderate myopia adolescents by using optical coherence tomography angiography.METHODS:Children aged 10 to 14y with a cycloplegic spherical equivalent refraction of−0.50 diopter(D)to−5.00 D and astigmatism with more than−1.50 D were recruited.The enrolled adolescents were divided into OK group and spectacle group.During regular followup,adolescents were measured respectively at pre-wear,1,3,and 6mo after treatment.The follow-up included uncorrected distance visual acuity(UDVA),axial length(AL),superficial capillary plexus density(SCPD),deep capillary plexus density(DCPD),central retinal thickness(CRT),foveal avascular zone area(FAZ-A),foveal avascular zone perimeter(FAZ-P)and foveal vessel density in a 300-μmwide region around foveal avascular zone(FD-300).The collected data were analyzed using statistical methods.RESULTS:By one month,SCPD significantly increased in the fovea and superior retina,and DCPD significantly increased inferiorly in OK group compared to spectacle group(P<0.05).By three months,there were significant increases in SCPD in the fovea and inferior retina,and DCPD in the parafovea,superior,and inferior retina in OK group(P<0.05),while the increase in SCPD and DCPD in the fovea were observed by six months(P<0.05).The FD-300 significantly increased at every follow-up in OK group compared to spectacle group(P<0.05).No significant differences in the CRT,FAZ-A and FAZ-P and FD-300 were observed between two groups(P>0.05).OK group showed a significant improvement in UDVA after wearing OK,compared to spectacle group(P<0.01),while the AL did not show a significant difference between two groups(P>0.05).CONCLUSION:Short-term OK worn can increase local retinal vessel density in adolescents with low-to-moderate myopia.

关 键 词：optical coherence tomography angiography ORTHOKERATOLOGY MYOPIA axial length retinal capillary plexus density 

分 类 号：R749.16[医药卫生—神经病学与精神病学]