杂化纳米材料光热治疗肿瘤的研究进展  

Advances in Photothermal Therapy of Tumors Using Hybrid Nanomaterials

作　　者：黄小秀 李虎 杨松 HUANG Xiaoxiu;LI Hu;YANG Song(Panzhou People’s Hospital,Liupanshui 553500,China;Center for Research&Development of Fine Chemicals,Guizhou University,Guiyang 550025,China)

机构地区：[1]盘州市人民医院,贵州六盘水553500 [2]贵州大学精细化工研究开发中心,贵州贵阳550025

出　　处：《贵州大学学报（自然科学版）》2023年第5期37-46,共10页Journal of Guizhou University:Natural Sciences

基　　金：国家自然科学基金资助项目(21908033);霍英东教育基金资助项目(161030);贵州省S&T项目(ZK[2022]011)。

摘　　要：光热治疗(photothermal therapy,PTT)具有高效快速、侵入性小、无创等优点。通常在光热治疗中采用单一的纳米材料作为光热剂,然而使用单一纳米材料通常会面临生物相溶性差、稳定性差、毒性大、靶向性能差、缺少成像性等问题。本文主要综述了最近几年开发的杂化纳米材料,通过多种光热材料的掺杂、包覆、表面修饰等方法开发了碳基杂化、无机杂化、有机-无机杂化等具有优良光热性能的光热材料,解决了使用单一光热材料面临的问题。此外,通过融合光热材料、靶向材料、成像材料、化疗材料和放射性材料等达到联合协同治疗的效果。杂化材料促进高效治疗癌症技术的发展,为光热协同治疗提供材料支持。这些方法为进一步开发新型杂化光热材料提供了思路,有望基于当前报道的各类具有光热潜力的材料,开发出高光热效率、高安全性的杂化光热材料,使光热杂化纳米材料在肿瘤的治疗临床应用具有广阔的前景。Photothermal therapy(PTT)is an efficient,rapid,less invasive or even non-invasive technique.A single nanomaterial is usually used as a photothermal agent in the photothermal therapy,which,however,is affected by problems such as poor biocompatibility,poor stability,high toxicity,poor targeting performance,and lack of imaging.Therefore,the author mainly reviews the hybrid nanomaterials developed in recent years.Through a variety of photothermal materials doping,coating,surface modification and other methods,carbon-based hybrid,inorganic hybrid,organic-inorganic hybrid and other photothermal materials with excellent photothermal properties have been developed to solve the problems faced by using single photothermal materials.In addition,the fusion of photothermal materials,targeting materials,imaging materials,chemotherapy materials and radioactive materials are used to achieve the effect of joint synergistic therapy.Hybrid materials promote the development of efficient cancer treatment technology and supply material support for photothermal synergistic therapy.These methods provide ideas for the further development of new hybrid photothermal materials.It is expected to develop hybrid photothermal materials with high photothermal efficiency and high safety based on the currently reported materials with photothermal potential,which makes photothermal hybrid nanomaterials have broad prospects in the clinical photothermal therapy of tumors.

关 键 词：光热治疗 光热材料 靶向特异性 生物相容性 癌细胞 

分 类 号：TB383.1[一般工业技术—材料科学与工程] R730.5[医药卫生—肿瘤]