新型血栓标志物与脑白质病变程度的相关性分析  

Correlation of new thrombus markers with the degree of white matter lesions

作　　者：孟江涛 杨思宇 赵晓霞[2] MENG Jiangtao;YANG Siyu;ZHAO Xiaoxia(Fifth Clinical Medical College of Shanxi Medical University,Taiyuan 030000,China)

机构地区：[1]山西医科大学第五临床医学院,山西太原030000 [2]山西省人民医院,山西太原030000

出　　处：《中风与神经疾病杂志》2023年第8期730-734,共5页Journal of Apoplexy and Nervous Diseases

摘　　要：目的探讨凝血标志物血栓调节蛋白(TM)、组织型纤溶酶原激活剂-纤溶酶原激活剂抑制剂-1复合物(t-PAIC)表达与脑白质病变(WML)之间的相关性。方法选取2020年7月-2022年10月于山西省人民医院神经内科住院治疗的WML患者69例,入院后行新型凝血标志物检查,并完善头部核磁检查,根据Fazekas视觉评分法,对WML进行分级,采用Kendall′stau-b法分析WML患者新型凝血标志物与WML严重程度之间的相关性;采用多因素Logistic回归分析WML严重程度的影响因素。结果3组WML患者血清TM、t-PAIC之间具有差异性,与轻度组WML相比,中度组和重度组患者血清TM、t-PAIC水平均上升(P<0.05),血清TM、t-PAIC与3组患者患者WML严重程度之间具有相关性(P<0.05),高水平t-PAIC、年龄是影响WML加重的危险因素[OR(95%CI)=1.274(1.052~1.544)、1.063(1.015~1.114),P<0.05]。结论WML患者血清TM、t-PAIC表达与脑白质病变程度呈正相关,且t-PAIC是影响患者脑白质病变加重的危险因素,可能作为指示WML患者病情发展的血清标志物。Objective To investigate the correlation between the expression of coagulation markers thrombomodulin(TM)and tissue plasminogen activator-plasminogen activator inhibitor-1 complex(t-PAIC)and white matter lesions(WMLs).Methods A total of 69 patients with WMLs who were hospitalized in the Department of Neurology of Shanxi Provincial People's Hospital from July 2020 to October 2022 were selected.After admission,novel coagulation markers were tested,and cranial magnetic resonance examination was completed.WMLs were graded according to the Fazekas visual rating scale,and the correlation between novel coagulation markers and WML severity in patients with WMLs was analyzed by the Kendall stau-b method.Multivariate logistic regression was used to analyze the influencing factors for WML severity.Results There were significant differences in serum TM and t-PAIC levels between the mild,moderate,and severe WML groups,and the levels of serum TM and t-PAIC in the moderate and severe WML groups were significantly increased compared with the mild WML group(P<0.05).There was a correlation between serum TM and t-PAIC levels and the severity of WMLs in the three groups(P<0.05).The high level of t-PAIC and age were risk factors for the aggravation of WMLs,with odds ratios(95%confidence interval)of 1.274(1.052-1.544)and 1.063(1.015-1.114),respectively(P<0.05).Conclusion The expression of serum TM and t-PAIC in patients with WMLs is positively correlated with the degree of white matter lesions,and t-PAIC is a risk factor for the exacerbation of white matter lesions,which may be used as a serum marker to indicate the development of WML patients.

关 键 词：脑白质病变 血栓调节蛋白 组织型纤溶酶原激活剂-纤溶酶原激活剂抑制剂-1复合物 

分 类 号：R742[医药卫生—神经病学与精神病学]