穿支动脉粥样硬化病的临床研究进展  

Clinical research advances in branch atheromatous disease

作　　者：王幸(综述) 侯彦波[1] 朱辉[1] 刘晶瑶(审校)[1] WANG Xing;HOU Yanbo;ZHU Hui(Department of Neurology,Lequn Branch of The First Hospital of Jilin University,Changchun 130031,China)

机构地区：[1]吉林大学第一医院乐群院区神经内科,吉林长春130031

出　　处：《中风与神经疾病杂志》2023年第8期759-762,共4页Journal of Apoplexy and Nervous Diseases

基　　金：吉林省科技厅项目(20210101465JC)。

摘　　要：穿支动脉粥样硬化病(branch atheromatous disease,BAD)是指发生在穿支动脉开口或分叉处,由于动脉粥样硬化导致穿支动脉管腔狭窄或闭塞而形成的脑梗死。自BAD被提出后,因其在影像学上特征性的表现及易出现早期神经功恶化(early neurological deterioration,END)的临床特点而受到人们的关注。但因为穿支动脉在传统影像学上无法直观显示,导致BAD的诊断标准及治疗策略难以明确和统一。随着高分辨率磁共振及高场强磁共振等技术的应用,穿支动脉血流动力学及管腔内斑块等特征得以展现,这将极大地辅助于开展更多高水平的BAD相关研究。本文将对BAD的流行病学、临床及影像学表现、诊断标准、治疗方法等方面作如下综述,期望提高临床医生早期精准识别本病并为诊断及治疗提供参考。Branch atheromatous disease(BAD)refers to cerebral infarction that occurs at the opening or bifurcation of the perforating artery and is caused by the stenosis or occlusion of the lumen of the perforating artery due to atherosclerosis.Since BAD was proposed,it has attracted wide attention due to its characteristic imaging manifestations and clinical features of early neurological deterioration.However,since it is unable to visualize the perforating artery on conventional imaging,it is difficult to clarify and unify the diagnostic criteria and therapeutic strategies for BAD.The application of high-resolution magnetic resonance and high-field magnetic resonance can help to display the hemodynamics and luminal plaques of the perforating artery,which will provide assistance for the development of more high-level BAD studies.This article reviews the epidemiology,clinical and imaging manifestations,diagnostic criteria,and treatment of BAD,so as to improve the early identification of this disease among clinicians and provide a reference for the diagnosis and treatment of this diseases.

关 键 词：穿支动脉粥样硬化病 穿支动脉 早期神经功能恶化 动脉粥样硬化 

分 类 号：R743[医药卫生—神经病学与精神病学]