2000-2019年中国早发型胃癌和晚发型胃癌流行病学趋势分析  

Epidemiological trend of early-onset gastric cancer and late-onset gastric cancer in China from 2000 to 2019

作　　者：何敏均 季璐玓 连力 马占芳 罗煜橦 赖娇龙 王凯娟[1,2] He Minjun;Ji Ludi;Lian Li;Ma Zhanfang;Luo Yutong;Lai Jiaolong;Wang Kaijuan(School of Public Health,Zhengzhou University,Zhengzhou 450001,China;Key Laboratory of Tumor Epidemiology of Henan Province/State Key Laboratory of Esophageal Cancer Prevention&Treatment,Zhengzhou 450001,China)

机构地区：[1]郑州大学公共卫生学院,郑州450001 [2]河南省肿瘤流行病学重点实验室/省部共建食管癌防治国家重点实验室,郑州450001

出　　处：《中华流行病学杂志》2023年第8期1198-1202,共5页Chinese Journal of Epidemiology

基　　金：郑州大学大学生创新创业训练计划(2022cxcy579)。

摘　　要：目的了解我国早发型胃癌和晚发型胃癌2000-2019年发病、死亡状况的变化趋势。方法收集全球疾病负担研究数据,应用R 4.2.1软件分析中国人群2000-2019年不同性别、年龄和年份的胃癌发病率、死亡率及伤残调整生命年(DALY)等指标。结果2019年早发型胃癌和晚发型胃癌粗发病率为7.06/10万(95%UI:6.63/10万~7.59/10万)和114.52/10万(95%UI:108.79/10万~121.63/10万),粗死亡率分别为3.29/10万(95%UI:3.11/10万~3.50/10万)和81.88/10万(95%UI:78.15/10万~86.04/10万),粗DALY率分别为156.48/10万(95%UI:148.82/10万~165.84/10万)和1750.13/10万(95%UI:1661.21/10万~1852.99/10万)。早发型胃癌标化发病率由2000年的5.49/10万降至2019年的4.76/10万,晚发型由2000年的143.45/10万降至2019年的123.02/10万;早发型胃癌标化死亡率由2000年的4.16/10万降至2019年的2.18/10万,晚发型由2000年的140.82/10万降至2019年的91.49/10万。2019年早发型胃癌标化DALY率为105.87/10万(95%UI:87.98/10万~125.60/10万),低于2000年的198.84/10万(95%UI:179.47/10万~219.83/10万)。2019年晚发型胃癌标化DALY率为1821.11/10万(95%UI:1509.42/10万~2158.53/10万),低于2000年的2932.52/10万(95%UI:2665.92/10万~3252.60/10万)。结论2000-2019年中国早发型胃癌和晚发型胃癌标化发病率和标化死亡率总体呈下降趋势。2000-2019年晚发型胃癌发病率、死亡率和DALY负担远高于早发型胃癌。且男性发病率、死亡率及粗DALY率均高于女性。Objective In order to understand the changing trends of gastric cancer incidence and mortality in early-onset and late-onset in China from 2000 to 2019.Methods The Global Burden of Disease research data was collected,and Excel and R 4.2.1 softwares were used to examine the incidence rate,mortality rate,and disability-adjusted life years(DALY)of Chinese people from 2000 to 2019,with a focus on gender,age,and year.Results In 2019,the crude incidence rates were 7.06/100000(95%UI:6.63/100000-7.59/100000)and 114.52/100000(95%UI:108.79/100000-121.63/100000)for early-and late-onset gastric cancer,respectively.The crude mortality rate for early-onset gastric cancer was 3.29/100000(95%UI:3.11/100000-3.50/100000),while the crude mortality rate for late-onset gastric cancer was 81.88/100000(95%UI:78.15/100000-86.04/100000).Additionally,the crude DALY rates for these two types of gastric cancer were 156.48/100000(95%UI:148.82/100000-165.84/100000)and 1750.13/100000(95%UI:1661.21/100000-1852.99/100000).The standardized incidence of early-onset gastric cancer decreased from 5.49/100000 in 2000 to 4.76/100000 in 2019,and that of late-onset gastric cancer decreased from 143.45/100000 in 2000 to 123.02/100000 in 2019.The standardized mortality rate of early-onset gastric cancer decreased from 4.16/100000 in 2000 to 2.18/100000 in 2019,and that of late-onset gastric cancer decreased from 140.82/100000 in 2000 to 91.49/100000 in 2019.The standardized DALY rate for early-onset gastric cancer in 2019 was 105.87/100000(95%UI:87.98/100000-125.60/100000),lower than 198.84/100000(95%UI:179.47/100000-219.83/100000)in 2000.The standardized DALY rate for late onset gastric cancer in 2019 was 1821.11/100000(95%UI:1509.42/100000-2158.53/100000),lower than 2932.52/100000(95%UI:2665.92/100000-3252.60/100000)in 2000.Conclusions The standardized mortality rate of early-onset gastric cancer in China showed a decreasing trend from 2000 to 2019.The standardized mortality rate of late onset gastric cancer showed a trend of first increasing and then d

关 键 词：胃癌 发病率 死亡率 趋势 

分 类 号：R735.2[医药卫生—肿瘤] R181.3[医药卫生—临床医学]