介孔硅纳米载体应用于肿瘤治疗的研究进展  

Research Progress in the Application of Mesoporous Silica Nanoparticles in Tumor Therapy

作　　者：韩凯硕 任婷[1] 李多 孙国辉[1] 张娜[1] 赵丽娇[1] 钟儒刚[1] HAN Kai-shuo;REN Ting;LI Duo;SUN Guo-hui;ZHANG Na;ZHAO Li-jiao;ZHONG Ru-gang(Beijing Key Laboratory of Environmental&Viral Oncology,Faculty of Environment&Life,Beijing University of Technology,Beijing 100124,China)

机构地区：[1]北京工业大学、环境与生命学部、环境与病毒肿瘤学北京市重点实验室,北京100124

出　　处：《化学试剂》2023年第9期1-10,共10页Chemical Reagents

基　　金：北京市教委重点实验室项目(PXM2015-014204-500175);国家自然科学基金资助项目(82003599)。

摘　　要：化疗是临床上治疗恶性肿瘤的重要手段,但化疗药物毒副作用大、易产生耐药和生物相容性差等问题往往限制其治疗效果。纳米载体可使药物靶向作用于肿瘤部位,减少化疗药物对正常组织产生的毒副作用,从而提高治疗效果,近年来已成为癌症精准治疗领域中的研究热点。其中,介孔硅纳米粒子(Mesoporous silica nanoparticles,MSNs)作为一种无机纳米材料,具有比表面积大、孔径可调、孔体积大、生物相容性好和易于功能化修饰等优点,被广泛用于纳米递送系统的构建,尤其是集肿瘤靶向、治疗和成像等多种功能于一体的新型纳米递送系统。综述了近年来功能化MSNs递送载体应用于肿瘤靶向治疗、药物递送和肿瘤生物成像等方面的研究进展,为开发新型纳米递送系统以用于癌症治疗提供了参考。Chemotherapy is an important method of treating malignant tumors in clinical practice,but its therapeutic effect is often limited by the problems of high systemic toxicity,susceptibility to drug resistance,and poor biocompatibility.Nanocarriers enable drugs to targetedly act on tumor sites and reduce the toxic side effects of chemotherapeutics on normal tissues,thus improving the therapeutic effect,which has become a hot research topic in the field of cancer precision therapy in recent years.Among them,mesoporous silica nanoparticles(MSNs),a sort of inorganic nanomaterial,have the advantages of large specific surface area,adjustable pore size,large pore volume,favorable biocompatibility and easy functionalization modification.Therefore,MSNs have been widely used in the construction of nano-delivery systems,especially new nano-delivery systems that integrate multiple functions such as tumor targeting,therapy and imaging.The research progress of functionalized MSNs delivery carriers developed in recent years for targeted tumor therapy,drug delivery and tumor bioimaging was summarized,which is expected to provide a reference for the development of novel nanodrug delivery systems for cancer therapy.

关 键 词：介孔硅纳米载体 肿瘤靶向治疗 刺激响应 药物递送 生物成像 

分 类 号：R914[医药卫生—药物化学]