不同组织内YAP1、E-cadherin表达与上皮性卵巢癌患者临床病理特征间的关系分析  

Analysis of the relationship between the expression of YAP1 and E-cadherin in different tissues and the clinicopathological characteristics of epithelial ovarian cancer

作　　者：夏潇 王莹 韩灵云 韩恩善[3] XIA Xiao;WANG Ying;HAN Lingyun;HAN Enshan(Department of Pathology,Wuzhong People's Hospital,Wu Zhong 751100,China;Department of Gynaecology,Wuzhong People's Hospital,Wu Zhong 751100,China;Department of Pathology,General Hospital of Ningxia Medical University,Yinchuan 750004,China)

机构地区：[1]宁夏吴忠市人民医院病理科,宁夏吴忠751100 [2]宁夏吴忠市人民医院妇科,宁夏吴忠751100 [3]宁夏医科大学总医院病理科,宁夏银川750004

出　　处：《宁夏医学杂志》2023年第8期695-698,F0003,共5页Ningxia Medical Journal

摘　　要：目的研究不同组织内Yes相关蛋白1(YAP1)、上皮钙黏蛋白(E-cadherin)表达与上皮性卵巢癌患临床病理特征间的关系。方法回顾性分析确诊为上皮性卵巢癌并行卵巢切除术的57例患者的石蜡包埋的肿瘤组织标本,同时,收集石蜡包埋的癌旁正常卵巢组织标本,对癌组织及癌旁组织分别利用免疫组化法检测YAP1、E-cadherin表达。比较不同组织内YAP1、E-cadherin阳性检出率,不同临床病理特征上皮性卵巢癌患者YAP1、E-cadherin阳性检出率差异,对57例患者行3年院外随访,观察癌组织YAP1及E-cadherin阳性、阴性患者术后3年存活率差异。结果癌组织YAP1阳性检出53例(92.98%),癌旁组织YAP1阳性检出率7例(12.28%),癌组织E-cadherin阳性检出27例(47.37%),癌旁组织E-cadherin阳性检出2例(3.51%),癌组织YAP1及E-cadherin阳性检出率高于癌旁组织(P<0.05)。FIGO分期为Ⅲ~Ⅳ期患者癌组织YAP1阳性检出率明显增高(P<0.05);FIGO分期Ⅰ~Ⅱ期、分化程度高、淋巴结未转移患者癌组织E-cadherin阳性检出率增高(P<0.05)。57例经卵巢切除术治疗的患者3年死亡23例(40.35%),存活34例(59.65%);Kaplan-Meier生存分析显示,癌组织E-cadherin阳性检出率越高患者存活率越高(Log-Rank=4.752,P<0.05)。结论在上皮性卵巢癌中,YAP1呈高水平表达,且与临床分期有显著相关性;E-cadherin在上皮卵巢癌中表达上调,与疾病进展、转移等有关,但其表达随着临床分期、分化程度、淋巴结转移情况增加而下降,一定程度上可用来预测患者预后。Objective To study the relationship between the expression of Yes related protein 1(YAP1)and Epithelial cadherin(E-cadherin)in different tissues and the clinicopathological characteristics of epithelial ovarian cancer.Methods A retrospective analysis was conducted on paraffin-embedded tumor tissue samples from 57 patients diagnosed with epithelial ovarian cancer who underwent oophorectomy,and the paraffin-embedded paracancer normal ovarian tissue samples were collected simultaneously.Immunohistochemical methods were used to detect the expression of YAP1 and E-cadherin in the cancer tissue and paracancer tissue,respectively.Compared the positive detection rates of YAP1 and E-cadherin in different tissues,and compared the positive detection rates of YAP1 and E-cadherin in epithelial ovarian cancer patients with different clinicopathologic characteristics.57 patients were followed up for 3 years to observe the difference of 3-year survival rate of patients with positive and negative YAP1 and E-cadherin in the cancer tissues.Results The positive detection of YAP1 in cancer tissue was 53(92.98%),the positive detection of YAP1 in adjacent tissue was 7(12.28%),and the positive detection of E-cadherin in cancer tissue was 27(47.37%).The positive detection rate of E-cadherin in paracancer tissue was 2(3.51%),and the positive detection rates of YAP1 and E-cadherin in cancer tissue was significantly higher than those in paracancer tissue(P<0.05).while the positive detection rate of YAP1 in patients with FIGO stageⅢ-Ⅳwas significantly increased(P<0.05).The positive detection rate of E-cadherin in cancer tissues of patients with FIGO stageⅠ-Ⅱ,high differentiation degree and no lymph node metastasis was significantly increased(P<0.05).The 3-year mortality was 23(40.35%)and the survival rate was 34(59.65%).Kaplan-Meier survival analysis showed that the higher the positive rate of E-cadherin in cancer tissue,the higher the survival rate(Log-Rank=4.752,P<0.05).Conclusion In epithelial ovarian cancer,YAP1 is highly express

关 键 词：上皮性卵巢癌 Yes相关蛋白1 上皮钙黏蛋白 预后 

分 类 号：R737.31[医药卫生—肿瘤]