PET/CT影像组学结合LncRNA-DGCR5在NSCLC精准医疗中的应用研究  

Application of PET/CT radiomics combined with LncRNA-DGCR5 in precision medicine of NSCLC

作　　者：张振华 付伟 刘伟良 李俊彦 黄涛 胡辉 范志刚 ZHANG Zhenhua;FU Wei;LIU Weiliang;LI Junyan;HUANG Tao;HU Hui;FAN Zhigang(Department of Cardiothoracic Surgery,3201 Hospital,Xi'an 723000,China;Department of Medical Oncology,3201 Hospital,Xi'an 723000,China)

机构地区：[1]三二〇一医院心胸外科,723000 [2]三二〇一医院肿瘤内一科,723000

出　　处：《天津医药》2023年第9期1011-1015,共5页Tianjin Medical Journal

基　　金：陕西省重点研发计划项目(2021SF-044)。

摘　　要：目的研究PET/CT影像组学结合长链非编码RNA DiGeorge综合征临界区基因5(LncRNA-DGCR5)在非小细胞肺癌(NSCLC)精准医疗中的应用价值。方法106例NSCLC患者均接受PET/CT检查及放化疗治疗,根据治疗后实体肿瘤疗效评价标准(RECIST)对其进行疗效评价,将完全缓解和部分缓解患者纳入治疗有反应组(58例),疾病稳定和疾病进展患者纳入治疗无反应组(48例)。比较2组患者的PET/CT图像纹理参数[最大标准摄取值(SUV_(max))、平均值、方差、峰度、偏度、对比度、熵、能量];实时荧光定量PCR检测外周血LncRNA-DGCR5表达;构建受试者工作特性(ROC)曲线分析各指标对NSCLC患者疗效的预测价值。结果有反应组SUV_(max)、熵及LncRNADGCR5表达低于无反应组(P<0.05),能量高于无反应组(P<0.05),其余参数比较差异无统计学意义;以LncRNADGCR5表达均值2.01为临界值,将患者分为LncRNA-DGCR5低表达组(51例)和高表达组(55例),与LncRNADGCR5低表达组比较,LncRNA-DGCR5高表达组PET/CT纹理参数中SUV_(max)、熵升高,能量降低(P<0.05);ROC曲线结果显示,SUV_(max)、熵、能量及LncRNA-DGCR5预测NSCLC患者疗效的AUC分别为0.897、0.851、0.795和0.949,且联合预测的AUC最高,为0.998。结论PET/CT影像组学结合LncRNA-DGCR5有助于预测NSCLC患者的疗效,从而在NSCLC精准医疗中提供指导。Objective To study the application value of PET/CT radiomics combined with long noncoding RNA DiGeorge syndrome critical region gene 5(LncRNA-DGCR5)in the precision medicine of non-small cell lung cancer(NSCLC).Methods A total of 106 NSCLC patients received PET/CT examination and chemoradiotherapy,and their efficacy was evaluated according to the Evaluation Criteria for Solid Tumor Efficacy after Treatment(RECIST).Patients with complete remission and partial remission were included in the response group(58 cases),and patients with stable or progressive disease were included in the non-response group(48 cases).Image texture parameters of PET/CT including SUV_(max)(maximum standard value),mean value,variance,kurtosis,skewness,contrast,entropy and energy were compared between groups.Real-time fluorescence quantitative PCR was used to detect LncRNA-DGCR5 expression in peripheral blood.Receiver operating characteristic curve(ROC)was constructed to analyze the predictive value of each index to the therapeutic efficacy of NSCLC patients.Results The SUV_(max)value,entropy and expression of LncRNA-DGCR5 were significantly lower in the response group than those in the non-response group(P<0.05),and the energy was significantly higher in the response group than that in the non-response group(P<0.05).There were no significant differences in the other parameters between the two groups.Patients were divided into the low LncRNA-DGCR5 expression group(51 cases)and the high LncRNA-DGCr5 expression group(55 cases)according to the mean expression of LncRNA-DGCR5(2.01)as the critical value.Compared with the low LncRNA-DGCR5 expression group,the PET/CT image texture parameters of SUV_(max)and entropy were significantly increased in the high LncRNA-DGCR5 expression group,and the energy was significantly decreased(P<0.05).ROC curve construction showed that the AUCs of SUV_(max)value,entropy,energy and LncRNA-DGCR5 expression on predicting the treatment efficacy of patients with NSCLC were 0.897,0.851,0.795 and 0.949 respectively,and th

关 键 词：癌 非小细胞肺 体层摄影术 发射型计算机 RNA 长链非编码 DiGeorge综合征临界区基因5 精准医疗 

分 类 号：R734.2[医药卫生—肿瘤] R814.42[医药卫生—临床医学]