中药单体调控AMPK/mTOR通路介导自噬防治糖尿病肾脏病的研究进展  

Active Components in Chinese Medicinal Herbs Regulate AMPK/mTOR Pathway to Mediate Autophagy in Diabetic Kidney Disease:A Review

作　　者：任梦涵 杨丽霞[2] 梁永林[1] 李次艳 REN Menghan;YANG Lixia;LIANG Yonglin;LI Ciyan(Gansu University of Chinese Medicine,Lanzhou 730000,China;Gansu Province Academy of Chinese Medicine,Lanzhou 730050,China)

机构地区：[1]甘肃中医药大学,兰州730000 [2]甘肃省中医药研究院,兰州730050

出　　处：《中国实验方剂学杂志》2023年第18期277-282,共6页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：甘肃省高等学校产业支撑计划项目(2021CYZC-03)。

摘　　要：糖尿病肾脏病(DKD)是糖尿病患者最典型的微血管并发症之一,是导致终末期肾病的重要原因,其发病机制尚未完全阐明,可能主要与血流动力学效应、遗传因素、肾脏炎性损伤、氧化应激、自噬失调、代谢紊乱等密切相关。因其发生机制复杂,临床上尚无特异性防治措施。腺苷酸活化蛋白激酶(AMPK)/哺乳动物雷帕霉素哺乳靶蛋白(mTOR)信号通路是参与自噬调节的一个经典通路,可通过激活自噬途径达到治疗DKD的效果。近年来,中药单体因其能够直接作用于靶向细胞,自噬靶点等优势在DKD的防治中扮演着重要角色,受到国内外学者的广泛关注。目前,相关研究人员对DKD的发生发展及药物干预治疗DKD中的病理生理机制做了大量研究,结果发现AMPK/mTOR通路在疾病的发展过程中发挥着重要作用,中药单体通过调控AMPK/mTOR信号通路的活性进而影响自噬途径,减轻氧化应激、炎症和细胞外基质的过度聚集,促进自噬小体的生成,从而改善肾脏的损伤。该文将主要从AMPK/mTOR信号通路介导自噬与DKD的关系及中药单体通过AMPK/mTOR通路介导自噬治疗DKD的作用机制作一综述,以期为临床防治DKD提供丰富地理论依据及思路。Diabetic kidney disease(DKD)is one of the typical microvascular complications in patients with diabetes and a major cause of end-stage renal disease,with the pathogenesis remains to be elucidated.It may be associated with hemodynamic effects,genetic factors,kidney inflammatory injury,oxidative stress,autophagy dysregulation,metabolic disorders and so on.Because of its complex mechanism,there are no specific prevention and treatment measures in clinical practice.AMP-activated protein kinase(AMPK)/mammalian target of rapamycin(mTOR)signaling pathway is a classical pathway involved in the regulation of autophagy.This pathway can be activated for treating DKD.Recent studies have demonstrated that the active components in Chinese medicinal herbs play a role in the prevention and treatment of DKD by directly acting on targeted cells and autophagy targets,which has attracted extensive attention.Researchers have extensively studied the occurrence and development of DKD and the mechanism of drug intervention in DKD,and the results prove that AMPK/mTOR pathway plays a role in the development of this disease.The active components in Chinese medicinal herbs regulate the AMPK/mTOR signaling pathway to affect autophagy,alleviate oxidative stress,inflammation,and extracellular matrix aggregation,and promote the generation of autophagosomes,thus mitigating kidney injury.This paper mainly reviews the relationship between AMPK/mTOR signaling pathway,autophagy,and DKD and the mechanism of active components in Chinese medicinal herbs in mediating autophagy via the AMPK/mTOR pathway,aiming to provide a theoretical basis for the clinical prevention and treatment of DKD.

关 键 词：腺苷酸活化蛋白激酶(AMPK)/哺乳动物雷帕霉素哺乳靶蛋白(mTOR)信号通路 中药单体 自噬 糖尿病肾脏病 研究进展 

分 类 号：R22[医药卫生—中医基础理论] R242[医药卫生—中医学] R96R587.2R692.9