注射用血栓通联合吡拉西坦氯化钠注射液治疗急性脑梗死效果的倾向性评分匹配研究  

Propensity score matching study on the effect of Xueshuantong for injection combined with Piracetam sodium chloride injection in the treatment of acute cerebral infarction

作　　者：朱志辉 金罗剑 李炜 Zhu Zhihui;Jin Luojian;Li Wei(The People's Hospital of Dexing City,Dexing,Jiangxi 334000)

机构地区：[1]德兴市人民医院,江西德兴334000

出　　处：《基层医学论坛》2023年第22期15-17,21,共4页The Medical Forum

基　　金：江西省卫生健康委科技计划项目(202212715)。

摘　　要：目的探讨注射用血栓通联合吡拉西坦氯化钠注射液在急性脑梗死(acute cerebral infarction,ACI)患者中的疗效。方法回顾性分析德兴市人民医院2019年1月—2020年12月收治的ACI患者的临床资料,采用倾向性评分匹配分析患者年龄、梗死部位、梗死面积、入院时间、合并慢性病等基线资料,采用近邻法进行1∶1匹配,纳入观察组、对照组各30例。2组均实施常规抗血小板聚集、抗凝、稳定斑块、营养神经、控制基础病等治疗,对照组在此基础上应用吡拉西坦氯化钠注射液治疗,观察组在对照组基础上联合注射用血栓通治疗,持续治疗2周。比较2组临床疗效、神经功能[美国国立卫生研究院卒中量表(national institute of health stroke scale,NIHSS)]、日常生活能力[Barthel指数(barthel index,BI)]、血液流变学改善情况[红细胞压积(hematocrit,HCT)、全血高切黏度(whole blood high shear rate,HBV)、全血低切黏度(whole blood low shear rate,LBV)、纤维蛋白原(fibeinogen,FIB)]及不良反应。结果与对照组相比,观察组临床总有效率较高,差异有统计学意义(P<0.05);与对照组治疗后相比,观察组NIHSS评分较低,BI评分较高,差异有统计学意义(P<0.05);观察组治疗后HCT、HBV、LBV、FIB水平均低于对照组,差异有统计学意义(P<0.05);2组不良反应相比,差异无统计学意义(P>0.05)。结论注射用血栓通联合吡拉西坦氯化钠注射液在ACI患者治疗中具有较好疗效,能够有效改善神经功能与血液流变学指标水平,提升患者日常生活能力,且不良反应发生率低,安全性较高。Objective To investigate the efficacy of Xueshuantong for injection combined with Piracetam sodium chloride injection in patients with acute cerebral infarction(ACI).Methods The clinical data of ACI patients admitted to our hospital from January 2019 to December 2020 were retrospectively analyzed,and baseline data such as age,infarct location,infarct size,admission time,and chronic diseases were analyzed by propensity score matching.1:1 matching was performed,and the observation group and the control group were included,with 30 cases in each.Both groups were routinely treated with anti-platelet aggregation,anticoagulation,plaque stabilization,neurotrophic,and underlying disease control.On this basis,the control group was treated with Piracetam and Sodium Chloride Injection,and the observation group was treated with Xueshuantong for injection on the basis of the control group,and the treatment continued for 2 weeks.The clinical efficacy,neurological function[National Institutes of Health Stroke Scale(NIHSS)],activities of daily living[Barthel Index(BI)rating scale],hemorheological improvement[hematocri(t HCT),whole blood high shear viscosity(HBV),whole blood low shear viscosity(LBV),fibrinogen(FIB)]and adverse reactions were compared between the two groups.Results Compared with the control group,the total clinical effective rate of the observation group was higher(P<0.05).Compared with the control group after treatment,the NIHSS score of the observation group was lower and the Bi score was higher,(P<0.05).The levels of HCT,HBV,LBV and Fib in the observation group were lower than those in the control group after treatmen(t P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion Xueshuantong for injection combined with piracetam sodium chloride injection has a good curative effect in the treatment of patients with acute cerebral infarction,can effectively improve the level of neurological function and hemorheology indexes,improve the ability of daily life,and the in

关 键 词：急性脑梗死 血栓通 吡拉西坦氯化钠注射液 倾向性评分匹配 治疗效果 

分 类 号：R743.3[医药卫生—神经病学与精神病学]