血清癌胚抗原、血管内皮生长因子水平与妇科恶性肿瘤合并糖尿病病人术后复发的相关性研究  

Correlation between serum CEA and VEGF levels and postoperative recurrence in patients with gynecological malignancies complicated with diabetes mellitus

作　　者：季秀芳 马艳[1] 木朝宇 JI Xiufang;MA Yan;MU Zhaoyu(Department of Obstetrics and Gynecology,General Hospital of Miners,Huaibei City,Huaibei,Anhui 235000,China)

机构地区：[1]淮北矿工总医院妇产科,安徽淮北235000

出　　处：《安徽医药》2023年第10期2041-2045,共5页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探究癌胚抗原(CEA)、血管内皮生长因子(VEGF)水平与妇科恶性肿瘤并发2型糖尿病(T2DM)病人术后复发的关系。方法回顾性研究2017年2月至2021年2月于淮北矿工总医院行手术治疗的110例妇科恶性肿瘤并发T2DM病人为合并T2DM组,另纳入同期于该院行手术治疗的55例无T2DM妇科恶性肿瘤病人为无合并T2DM组,比较无合并T2DM组、合并T2DM组病人血清CEA,VEGF,糖类抗原(CA)125、CA199水平。对所有妇科恶性肿瘤并发T2DM病人随访1年,按其是否发生术后复发分为未复发组(n=72)、复发组(n=38),比较未复发组、复发组妇科恶性肿瘤并发T2DM病人一般资料及血清CEA、VEGF、CA125、CA199水平;分析妇科恶性肿瘤并发T2DM病人术后复发的影响因素;分析血清CEA、VEGF对妇科恶性肿瘤并发T2DM病人术后复发的预测价值。结果合并T2DM组病人血清CEA(54.52±18.17)μg/L、VEGF(371.93±123.98)ng/L、CA125(37.48±12.51)U/mL、CA199(41.56±13.85)U/mL水平均高于无合并T2DM组病人血清CEA(28.74±9.58)μg/L、VEGF(195.04±65.01)ng/L、CA125(20.76±6.94)U/mL、CA199(28.37±9.46)U/mL(均P<0.05);复发组妇科恶性肿瘤并发T2DM病人血清CEA、VEGF、糖化血红蛋白(HbA1c)水平均高于未复发组(均P<0.05);CEA、VEGF是妇科恶性肿瘤并发T2DM病人术后复发的影响因素(均P<0.05);血清CEA、VEGF预测妇科恶性肿瘤并发T2DM病人术后复发的曲线下面积(AUC)为0.85、0.89,截断值为72.79μg/L、397.73 ng/L,灵敏度为76.3%、78.9%,特异度为87.5%、89.9%,且血清CEA、VEGF联合预测妇科恶性肿瘤并发T2DM病人术后复发的AUC为0.96,其灵敏度为92.1%,特异度为86.1%。结论CEA、VEGF在妇科恶性肿瘤并发T2DM病人血清中水平较高,均与病人术后复发明显相关,且两者联合更有利于预测妇科恶性肿瘤并发T2DM病人术后复发情况。Objective To investigate the relationship between the levels of carcinoembryonic antigen(CEA)and vascular endothelial growth factor(VEGF)and postoperative recurrence in patients with gynecological malignancies complicated with type 2 diabetes mellitus(T2DM).Methods A retrospective study a total of 110 patients with gynecological malignant tumor complicated with T2DM who underwent surgical treatment in our hospital from February 2017 to February 2021 were gathered as the T2DM group.Another 55 patients with gynecological malignancies without T2DM who underwent surgical treatment in our hospital were included in the non-T2DM group.The serum levels of CEA,VEGF,and carbohydrate antigen 125/199(CA125/CA199)were compared between the non-T2DM group and the T2DM group.All patients with gynecological malignancies complicated with T2DM were followed up for 1 year,and were grouped into non-recurrence group(n=72)and recurrence group(n=38)according to whether they had postoperative recurrence or not.The general data and the levels of serum CEA,VEGF,CA125 and CA199 in patients with gynecological malignant tumor complicated with T2DM in the non-recurrence group and the recurrence group were compared;the influencing factors of postoperative recurrence in patients with gynecological malignancies complicated with T2DM were analyzed;the predictive value of serum CEA and VEGF for postoperative recurrence in patients with gynecological malignancies complicated with T2DM was analyzed.Results The levels of serum CEA(54.52±18.17)μg/L,VEGF(371.93±123.98)ng/L,CA125(37.48±12.51)U/mL,CA199(41.56±13.85)U/mL in patients with T2DM group were higher than those in non-T2DM group CEA(28.74±9.58)μg/L,VEGF(195.04±65.01)ng/L,CA125(20.76±6.94)U/mL,CA199(28.37±9.46)U/mL(all P<0.05);the levels of serum CEA,VEGF and glycosylated hemoglobin(HbA1c)in patients with gynecological malignant tumor complicated with T2DM in the recurrence group were higher than those in the non-recurrence group(all P<0.05);CEA and VEGF were the influencing factors of p

关 键 词：生殖器肿瘤 女(雌)性 癌胚抗原 2型糖尿病 血管内皮生长因子 术后复发 

分 类 号：R737.3[医药卫生—肿瘤] R587.1[医药卫生—临床医学]