急性脑梗死病人血清壳三糖苷酶1和几丁质酶3样蛋白1表达水平与预后的关系  

Relationship between serum CHIT1 and CHI3L1 expression levels and prognosis in patients with acute cerebral infarction

作　　者：汪莹 沈露[2] WANG Ying;SHEN Lu(Laboratory Department,Xianning Central Hospital(The First Affiliated Hospital of Hubei University of science and Technology),Xianning,Hubei 437100,China;Department of Neurology,Xianning Central Hospital(The First Affiliated Hospital of Hubei University of science and Technology),Xianning,Hubei 437100,China)

机构地区：[1]咸宁市中心医院(湖北科技学院附属第一医院),检验科,湖北咸宁437100 [2]咸宁市中心医院(湖北科技学院附属第一医院),神经内科,湖北咸宁437100

出　　处：《安徽医药》2023年第10期2055-2058,共4页Anhui Medical and Pharmaceutical Journal

基　　金：咸宁市中心医院2020年度院级一般项目(2020XYB008)。

摘　　要：目的检测急性脑梗死病人血清壳三糖苷酶1(CHIT1)和几丁质酶3样蛋白1(CHI3L1)的表达水平,并探讨其与病人预后的关系。方法选择2018年12月至2020年12月咸宁市中心医院接收的96例急性脑梗死病人作为疾病组,根据预后情况分为预后良好组(52例)和预后较差组(44例)。同期在咸宁市中心医院进行体检的96例健康者作为健康组。使用酶联免疫吸附实验(ELISA)检测血清CHIT1和CHI3L1表达水平;多因素logistic回归分析急性脑梗死病人90 d预后的影响因素;ROC曲线分析血清CHIT1和CHI3L1水平预测急性脑梗死病人90 d预后的价值。结果相比于健康组,疾病组血清CHIT1和CHI3L1的表达水平显著增加[(55.33±8.97)比(23.28±6.13)μg/L,(76.04±11.53)比(34.86±7.21)μg/L,P<0.05];预后较差组病人血清CHIT1和CHI3L1的表达水平显著高于预后良好组[(63.44±9.86)比(48.46±7.70)μg/L,(91.41±17.68)比(63.03±13.13)μg/L,P<0.05];血清CHIT1和CHI3L1可作为急性脑梗死病人90 d预后的影响因素(P<0.05);CHIT1和CHI3L1联合预测急性脑梗死病人90 d预后的曲线下面积(AUC)明显大于CHIT1和CHI3L1单一指标(P<0.05)。结论急性脑梗死病人血清中CHIT1和CHI3L1表达水平增加,与病人的预后有关,可用于预测急性脑梗死病人短期预后,具有作为预后标志物的潜力。Objective To detect the expression levels of serum chitotriosidase 1(CHIT1)and chitinase 3-like protein 1(CHI3L1)in patients with acute cerebral infarction,and to explore their relationship with the prognosis of patients.Methods A total of 96 patients with acute cerebral infarction admitted to the Xianning Central Hospital from December 2018 to December 2020 were gathered as the disease group,and they were assigned into a good prognosis group(52 cases)and a poor prognosis group(44 cases)according to their prognosis.In the same period,96 healthy subjects who underwent physical examination in Xianning Central Hospital were selected as the health group.The expression levels of CHIT1 and CHI3L1 in serum were measured by enzyme-linked immunosorbent assay(ELISA);the influencing factors of 90-day prognosis in patients with acute cerebral infarction were analyzed by multivariate logistic regression;the value of serum CHIT1 and CHI3L1 levels in predicting 90-day prognosis in patients with acute cerebral infarction was analyzed by ROC curve.Results Compared with the healthy group,the expression levels of serum CHIT1 and CHI3L1 in the disease group were obviously increased[(55.33±8.97)vs.(23.28±6.13)μg/L,(76.04±11.53)vs.(34.86±7.21)μg/L,P<0.05];the expression levels of serum CHIT1 and CHI3L1 in the poor prognosis group were obviously higher than those in the good prognosis group[(63.44±9.86)vs.(48.46±7.70)μg/L,(91.41±17.68)vs.(63.03±13.13)μg/L,P<0.05];serum CHIT1 and CHI3L1 can be used as the influencing factors of 90 day prognosis in patients with acute cerebral infarction(P<0.05);the area under curve(AUC)of the combination of CHIT1 and CHI3L1 in predicting the 90 day prognosis of patients with acute cerebral infarction was significantly greater than that of the single index of CHIT1 and CHI3L1(P<0.05).Conclusions The expression levels of CHIT1 and CHI3L1 in serum of patients with acute cerebral infarction are increased,which are related to the prognosis of patients.They can be used to predict the short-term pr

关 键 词：脑梗死 壳三糖苷酶1 几丁质酶3样蛋白1 预后 

分 类 号：R743.33[医药卫生—神经病学与精神病学]