胃癌前病变患者病变组织c-Myc蛋白表达情况及其与内镜黏膜下剥离术后复发的关系  

Expression of c-Myc protein in lesion tissues of patients with gastric precancerous lesions and its relation with recurrence after endoscopic submucosal dissection

作　　者：郑倩[1] 谭斌[1] 曹慧秋[1] 刘汉雄[1] ZHENG Qian;TAN Bin;CAO Huiqiu;LIU Hanxiong(Department of Gastroenterology,the First People′s Hospital of Chenzhou,Chenzhou 423000,Hunan,China)

机构地区：[1]郴州市第一人民医院消化内科,湖南省郴州市423000

出　　处：《广西医学》2023年第13期1525-1528,共4页Guangxi Medical Journal

基　　金：湖南省科技创新计划项目(2020SK50307)。

摘　　要：目的探讨胃癌前病变患者病变组织c-Myc蛋白表达情况及其与内镜黏膜下剥离术(ESD)后复发的关系。方法回顾性分析143例行ESD治疗的胃癌前病变患者的临床资料,采用免疫组化法检测病变组织及病变旁组织c-Myc蛋白表达情况。术后对患者进行为期1年的随访,根据复发情况将患者分为复发组与未复发组,并比较复发组与未复发组患者病变组织的c-Myc蛋白表达情况。采用多因素Logistic回归模型分析胃癌前病变患者ESD后复发的影响因素。结果胃癌前病变患者病变组织的c-Myc蛋白阳性表达率高于病变旁组织(P<0.05)。随访1年期间,有25例(17.48%)患者复发,复发组患者病变组织的c-Myc蛋白阳性表达率高于非复发组(P<0.05)。多因素Logistic回归分析结果显示,胃溃疡病史、吸烟史、服用非甾体抗炎药、主食汤泡饭、进食速度快、c-Myc蛋白高阳性表达均为胃癌前病变患者ESD后复发的危险因素(均P<0.05)。结论胃癌前病变患者病变组织c-Myc蛋白呈高表达,胃溃疡病史、吸烟史、服用非甾体抗炎药、主食汤泡饭、进食速度快、c-Myc蛋白高阳性表达均为胃癌前病变患者ESD后复发的危险因素。Objective To investigate the expression of c-Myc protein in lesion tissues of patients with gastric precancerous lesions and its relation with recurrence after endoscopic submucosal dissection(ESD).Methods The clinical data of 143 patients with gastric precancerous lesions who underwent ESD for treatment were retrospectively analyzed.The expressions of c-Myc protein in lesion tissues and tissues adjacent to lesions were detected by the immunohistochemistry.Patients were followed up for 1 year after operation,and they were divided into recurrence group or non-recurrence group according to recurrence status.The c-Myc protein expression of patients in lesion tissues was compared between the recurrence group and the non-recurrence group.The multivariate Logistic regression model was used to analyze the influencing factors for recurrence of patients with gastric precancerous lesions after ESD.Results The positive expression rate of c-Myc protein in lesion tissues of patients with gastric precancerous lesions was higher than that in tissues adjacent to lesions(P<0.05).During 1 year of follow-up,25(17.48%)patients relapsed,and the positive expression rate of c-Myc protein in lesion tissues of the recurrence group was higher than that of the non-recurrence group(P<0.05).The results of multivariate Logistic regression analysis revealed that history of gastric ulcer,smoking history,administration of non-steroidal anti-inflammatory drugs,rice in soup as main course,fast eating,and highly positive expression of c-Myc protein were all the risk factors for recurrence of patients with gastric precancerous lesions after ESD(all P<0.05).Conclusion c-Myc protein in lesion tissues is highly expressed in patients with gastric precancerous lesions,history of gastric ulcer,smoking history,administration of non-steroidal anti-inflammatory drugs,rice in soup as main course,fast eating,and highly positive expression of c-Myc protein are the risk factors for patients with gastric precancerous lesions after ESD.

关 键 词：胃癌前病变 C-MYC蛋白 内镜黏膜下剥离术 复发 影响因素 

分 类 号：R735.2[医药卫生—肿瘤]