紫杉醇与卡铂化疗同步放疗联合加味补中益气汤治疗宫颈癌合并放射性结肠炎的临床疗效  

Clinical efficacy analysis of paclitaxel and carboplatin chemotherapy with simultaneous radiotherapy combined with Jiawei Buzhong Yiqi decoction in the treatment of cervical cancer with radiation colitis

作　　者：任爱敏[1] Ren Aimin(Department of Gynecology,Anyang Cancer Hospital,Anyang Henan 455000,China)

机构地区：[1]河南省安阳市肿瘤医院妇科,河南安阳455000

出　　处：《中国药物与临床》2023年第2期91-94,共4页Chinese Remedies & Clinics

基　　金：河南省安阳市科技攻关项目(ky3-1-11)。

摘　　要：目的探讨紫杉醇与卡铂化疗同步放疗联合加味补中益气汤治疗宫颈癌合并放射性结肠炎的临床疗效。方法回顾性分析河南省安阳市肿瘤医院2020年10月至2022年1月收治的80例宫颈癌合并放射性结肠炎患者作为研究对象,分析患者临床病历资料后根据治疗方案将患者分为对照组与观察组,每组各40例。对照组接受紫杉醇与卡铂化疗同步放疗,观察组进一步联合加味补中益气汤治疗,2组患者均治疗6周。对比2组患者治疗前后C反应蛋白(CRP)、宫颈癌相关抗原(TA4)、血管内皮生长因子(VEGF)水平及实体瘤疗效与不良反应。结果观察组的客观缓解率(85%)、疾病控制率(98%)均高于对照组(60%,82%)(χ^(2)=6.270、5.000,P均<0.05);治疗前2组的CRP、TA4、VEGF差异无统计学意义(P>0.05),治疗后观察组的CRP、TA4、VEGF低于对照组(P<0.05);观察组发生肝功能损害5例(12%)、尿路刺激征3例(8%)、血尿1例(2%)、神经毒性5例(12%),不良反应14例(35%);对照组发生肝功能损害6例(15%)、尿路刺激征4例(10%)、血尿2例(5%)、神经毒性4例(10%),不良反应16例(40%);2组不良反应对比观察组明显低于对照组,差异有统计学意义(χ^(2)=0.052,P<0.05)。结论紫杉醇与卡铂化疗同步放疗联合加味补中益气汤可有效抑制宫颈癌合并放射性结肠炎患者肿瘤生长,减轻局部炎症并改善肿瘤标志物表达水平。Objective To investigate the clinical efficacy of paclitaxel and carboplatin chemotherapy with concurrent radiotherapy combined with Jiawei Buzhong Yiqi Decoction in the treatment of cervical cancer complicated with radiation colitis.Methods A retrospective analysis selected 80 patients with cervical cancer combined with radiation colitis who were admitted to Anyang Cancer Hospital from October 2020 to January 2022 as the research objects,and after analysing the patients′clinical history data,the patients were divided into control group and observation group,40 cases in each group.The control group received concurrent radiotherapy with paclitaxel and carboplatin chemotherapy,and the observation group was further combined with Jiawei Buzhong Yiqi Decoction,both groups were treated for 6 weeks.The levels of C-reactive protein(CRP),cervical cancer-associated anti-gen(TA4),vascular endothelial growth factor(VEGF),and the efficacy and side effects of solid tumors were com-pared between the two groups before and after treatment.Results The objective remission rate(85%vs 60%)and disease control rate(98%vs 82%)of the observation group were higher than those of the control group(P<0.05);there was no statistical difference in CRP,TA4 and VEGF between the two groups before treatment after treatment,CRP,TA4 and VEGF in the observation group were lower than those in the control group(P<0.05);5 cases of liver function damage(12%)and 3 cases of urinary tract irritation in the observation group(8%)occurred in the observation group),1 case(2%)of hematuria,5 cases of neurotoxicity(12%),and a total of 14 cases(35%)of toxic side effects;in the control group,6 cases(15%)of liver function damage and 4 cases of urinary tract irritation syndrome(10%),2 cases of hematuria(5%),4 cases of neurotoxicity(10%),and a total of 16 cases of toxic and side effects(40%).The comparison of toxic and side effects between the two groups showed that the observation group was significantly lower than the control group,and the difference was statistical

关 键 词：宫颈肿瘤 结肠炎 紫杉醇 放射治疗 卡铂 

分 类 号：R737.33[医药卫生—肿瘤]