康复新液联合替硝唑含漱液治疗固定正畸牙龈炎患者的效果  

Effects of Kangfuxin liquid combined with Tinidazole gargle in treatment of gingivitis patients undergoing fixed orthodontic treatment

作　　者：张晶晶 ZHANG Jingjing(Department of Stomatology of Zhoukou Stomatological Hospital,Zhoukou 466000 Henan,China)

机构地区：[1]周口口腔医院口腔内科,河南周口466000

出　　处：《中国民康医学》2023年第15期62-65,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察康复新液联合替硝唑含漱液治疗固定正畸牙龈炎患者的效果。方法:回顾性分析2021年8月至2022年8月该院收治的80例固定正畸牙龈炎患者的临床资料,按照治疗方案不同将其分为对照组和观察组各40例。对照组予以替硝唑含漱液治疗,观察组在对照组基础上联合康复新液治疗。比较两组临床疗效、治疗前后龈沟液指标[乳铁蛋白、白细胞介素-8(IL-8)、可溶性细胞间黏附分子-1(sICAM-1)、S100钙结合蛋白A12(S100A12)]水平、牙周指标[菌斑指数、牙龈指数、探诊深度、龈沟出血指数(SBI)]水平、疼痛数字评分量表(NRS)评分、简化口腔卫生指数中简化软垢指数(DI-S)评分,以及不良反应发生率。结果:观察组治疗总有效率为97.50%(39/40),高于对照组的80.00%(32/40),差异有统计学意义(P<0.05);治疗后,两组龈沟液乳铁蛋白、IL-8、sICAM-1、S100A12水平、菌斑指数、牙龈指数、SBI、NRS、DI-S评分和探诊深度均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组治疗期间均未见明显药物相关不良反应,安全性良好。结论:康复新液联合替硝唑含漱液治疗固定正畸牙龈炎患者可提高治疗总有效率,降低龈沟液指标水平、牙周指标水平、NRS评分和DI-S评分,效果优于单纯替硝唑含漱液治疗。Objective:To observe effects of Kangfuxin liquid combined with Tinidazole gargle in treatment of gingivitis patients undergoing fixed orthodontic treatment.Methods:The clinical data of 80 gingivitis patients undergoing fixed orthodontic treatment admitted to this hospital from August 2021 to August 2022 were retrospectively analyzed.According to different treatment options,they were divided into control group and observation group,40 cases in each.The control group was treated with Tinidazole gargle,while the observation group was treated with Kangfuxin liquid on the basis of that of the control group.The clinical efficacy,the gingival crevicular fluid index levels[lactoferrin,interleukin-8(IL-8),soluble intercellular adhesion molecule-1(sICAM-1),S100 calcium binding protein A12(S100 A12)],the periodontal index levels[plaque index,gingival index,probing depth,sulcus bleeding index(SBI)],the numerical rating scale(NRS)score,the simplified debris index(DI-S)score in simplified oral hygiene index,and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of treatment in the observation group was 97.50%(39/40),which was higher than 80.00%(32/40)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of lactoferrin,IL-8,sICAM-1,S100 A12,plaque index,gingival index,SBI,NRS,DI-S score and probing depth of gingival crevicular fluid in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There were no obvious drug-related adverse reactions during the treatment of the two groups,and the safety was good.Conclusions:Kangfuxin liquid combined with Tinidazole gargle in the treatment of the gingivitis patients undergoing fixed orthodontic treatment can improve the total effective rate of treatment and reduce the levels of gingival crevicular fluid indexes,perio

关 键 词：康复新液 替硝唑含漱液 固定正畸 牙龈炎 龈沟液 牙周指标 不良反应 

分 类 号：R781[医药卫生—口腔医学]