A comprehensive review of natural products with anti-hypoxic activity  

作　　者：LIU Juncai GE Zhen JIANG Xiao ZHANG Jingjing SUN Jianan MAO Xiangzhao 

机构地区：[1]College of Food Science and Engineering,Ocean University of China,Qingdao 266003,China [2]Medical College,Qingdao Binhai University,Qingdao 266555,China [3]Laboratory for Marine Drugs and Bioproducts,Qingdao National Laboratory for Marine Science and Technology,Qingdao 266237,China

出　　处：《Chinese Journal of Natural Medicines》2023年第7期499-515,共17页中国天然药物（英文版）

基　　金：supported by the Major Industrial Key Projects for the Transformation of New and Old Kinetic Energy in Shandong Province(No.202153);the Fundamental Research Funds for the Central Universities(No.201941002);China Agriculture Research System of MOF and MARA(No.CARS-48).

摘　　要：Natural products exhibit substantial impacts in the field of anti-hypoxic traetment.Hypoxia can cause altitude sickness and other negative effect on the body.Headache,coma,exhaustion,vomiting and,in severe cases,death are some of the clinical signs.Currently,hypoxia is no longer just a concern in plateau regions;it is also one of the issues that can not be ignored by urban residents.This review covered polysaccharides,alkaloids,saponins,flavonoids,peptides and traditional Chinese compound prescriptions as natural products to protect against hypoxia.The active ingredients,effectiveness and mechanisms were discussed.The related anti-hypoxic mechanisms involve increasing the hemoglobin(HB)content,glycogen content and adenosine triphosphate(ATP)content,removing excessive reactive oxygen species(ROS),reducing lipid peroxidation,regulating the levels of related enzymes in cells,protecting the structural and functional integrity of the mitochondria and regulating the expression of apoptosis-related genes.These comprehensive summaries are beneficial to anti-hypoxic research and provide useful information for the development of anti-hypoxic products.

关 键 词：Natural products ANTI-HYPOXIA Mechanism ACTIVITY 

分 类 号：R965[医药卫生—药理学]