基于二维NMR谱解析对碘苯甲酸乙酯结构的实验教学设计  

Experiments Teaching Design on 2D NMR Analysis of Ethyl P-iodobenzoate

作　　者：刘雅琴[1] 余明新[1] 何玲[1] LIU Yaqin;YU Mingxin;HE Ling(Department of Chemistry,Zhejiang University,Hangzhou 310027,China)

机构地区：[1]浙江大学化学系,杭州310027

出　　处：《实验室研究与探索》2023年第6期198-201,271,共5页Research and Exploration In Laboratory

基　　金：浙江省科技厅公益性技术应用研究计划项目(LGC19B050014);浙江大学实验技术项目(SJS202002)。

摘　　要：由于二维核磁共振波谱(NMR)技术对于确定化合物的结构非常有效,为了培养学生的独立解谱能力,开设了二维NMR谱的实验课程。以对碘苯甲酸乙酯为分析对象,对其一维和二维NMR谱信号进行完全归属,特别是在二维谱中,确认各组碳与氢的连接关系;化学键上相邻氢原子的耦合、远程相关和空间相关信息。该解析对象的结构相对较典型有效地让学生了解核磁共振波谱仪的性能和二维谱的应用。Nuclear magnetic resonance(NMR)is one of the crucial analytical methods in the characterization of organic structures.It is limited to one-dimensional hydrogen and carbon spectra,and it is difficult to carry out experimental teaching of two-dimensional spectra in universities,although NMR is widely used.In order to effectively broaden students’professional horizons and cultivate their independent spectral resolution ability,an experimental course on two-dimensional NMR spectroscopy has been established,due to the effectiveness of two-dimensional NMR technology in determining the structure of compounds.To confirm the connection relationship between each group of carbon and hydrogen,we use ethyl p-iodobenzoate as the analysis object,fully assign its one-dimensional and two-dimensional NMR spectrum signals.The structure of this analytical object is relatively typical and effective in enabling students to understand the performance of nuclear magnetic resonance spectrometers and the application of two-dimensional spectra,enabling large-scale instruments to fully support graduate teaching,further improving the utilization rate of analytical instruments,and laying a solid foundation for their future scientific research work.

关 键 词：二维核磁共振波谱 对碘苯甲酸乙酯 实验教学 大型仪器 

分 类 号：O657.63[理学—分析化学] G642.0[理学—化学]