Enantioselective Construction of Functionalized Thiochromans via Squaramide-Catalyzed Asymmetric Cascade Sulfa-Michael/Michael Addition  

作　　者：Yi Yang Daming Du 

机构地区：[1]School of Chemical Engineering and Environment,Beijing Institute of Technology,Beijing 100081,China

出　　处：《Chinese Journal of Chemistry》2014年第9期853-858,共6页中国化学（英文版）

基　　金：We are grateful for financial support from the National Natural Science Foundation of China(Grant No.21272024).

摘　　要：An efficient enantioselective cascade sulfa-Michael/Michael addition reaction of trans-3-(2-mercaptophenyl)-2-propenoic acid ethyl ester with nitroalkenes catalyzed by a chiral squaramide catalyst was disclosed.This cascade reaction afforded thiochroman derivatives with three contiguous stereocenters in high yields(up to 94%),excellent diastereoselectivities(up to>25∶1 dr)and enantioselectivities(up to 99% ee).

关 键 词：ORGANOCATALYSIS SQUARAMIDE Michael addition thiochromans CASCADE 

分 类 号：O62[理学—有机化学]