Primary-Tertiary Diamine/Brønsted Acid Catalyzed α-Allylation of Carbonyl Compounds with Allylic Alcohols  

作　　者：Lingyun Cui Long Zhang Sanzhong Luo Jin-Pei Cheng 

机构地区：[1]Beijing National Laboratory for Molecular Sciences(BNLMS),CAS Key Laboratory of Molecular Recognition and Function,Institute of Chemistry,Chinese Academy of Sciences,Beijing 100190,China

出　　处：《Chinese Journal of Chemistry》2014年第8期673-677,共5页中国化学（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China(21390400,21025208 and 21202171);the Ministry of Science and Technology(MoST)(2011CB808600)and the Chinese Academy of Sciences.

摘　　要：A simple and directα-allylic alkylation of unmodified aldehydes with allylic alcohols catalyzed by primary amine/Brønsted acid has been developed.The N,N-dimethylethylenediamine/TfOH was identified as the optimal catalyst to promote this transformation via an enamine process in high yields(up to 88%)and with good diastereoselectivities(up to 9∶1).

关 键 词：ORGANOCATALYSIS ENAMINE primary-tertiary diamine α-allylic alkylation 

分 类 号：O62[理学—有机化学]