Cu-Promoted Oxidative Trifluoromethylation of Terminal Alkynes with Difluoromethylene Phosphobetaine  

作　　者：Xiaoyun Deng Jinhong Lin Jian Zheng Jichang Xiao 

机构地区：[1]Key Laboratory of Organofluorine Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China

出　　处：《Chinese Journal of Chemistry》2014年第8期689-693,共5页中国化学（英文版）

基　　金：The authors thank the National Natural Science Foundation of China(NSFC)(Nos.21032006,21172240);the 973 Program of China(No.2012CBA01200);the Chinese Academy of Sciences for financial support.

摘　　要：Difluoromethylene phosphobetaine(Ph_(3)P^(+)CF_(2)CO_(2)^(-),PDFA),a known difluorocarbene reagent,was found to be able to efficiently trifluoromethylate terminal alkynes in the presence of Cu(I)and potassium fluoride.The transformation proceeded smoothly to afford the corresponding trifluoromethylated acetylenes in moderate yields.

关 键 词：COPPER difluoromethylene phosphobetaine TRIFLUOROMETHYLATION ALKYNES DIFLUOROCARBENE 

分 类 号：O62[理学—有机化学]