Nucleophilic Difluoro(phenylsulfonimidoyl)methylation of Unactivated Alkyl Bromides with PhSO(NTBS)CF_(2)H: Facile Entry into gem-Difluoroalkenes  

作　　者：Xiao Shen Qinghe Liu Chuanfa Ni Jinbo Hu 

机构地区：[1]Key Laboratory of Organofluorine Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China

出　　处：《Chinese Journal of Chemistry》2014年第8期703-708,共6页中国化学（英文版）

基　　金：Support of our work by the National Basic Research Program of China(Nos.2012CB215500 and 2012CB821600);the NNSFC(No.21372246);Shanghai QMX program(No.13QH1402400);the Chinese Academy of Sciences is gratefully acknowledged.

摘　　要：An efficient nucleophilic difluoro(phenylsulfonimidoyl)methylation of unactivated primary alkyl bromides with PhSO(NTBS)CF_(2)H has been developed.It is particularly remarkable that,when 1.5 equiv.of alkyl bromides are used,the substitution products are obtained in moderate to excellent yields.The prepared difluoro(phenylsulfonimidoyl)methylated alkanes can be readily transformed to gem-difluoroalkenes via base-mediatedβ-elimination reaction.

关 键 词：nucleophilic fluoroalkylation β-elimination difluoroalkene SULFOXIMINE 

分 类 号：O62[理学—有机化学]