New Lignans from the Leaves and Stems of Schisandra chinensis and Their Anti-HIV-1 Activities  

作　　者：Yiming Shi Weimao Zhong Huan Chen Ruirui Wang Shanzhai Shang Chengqin Liang Zhonghua Gao Yongtang Zheng Weilie Xiao Handong Sun 

机构地区：[1]State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming,Yunnan 650201,China [2]Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences&Yunnan Province,Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming,Yunnan 650223,China [3]University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Chinese Journal of Chemistry》2014年第8期734-740,共7页中国化学（英文版）

基　　金：the National Natural Science Foundation of China(Nos.81373290,81102483);the Natural Science Foundation of Yunnan Province(No.2012FB178);the Chinese Academy of Sciences grant(No.KSCX2-EW-Q-10);sponsored by the Scientific Research Foundation for the Returned Overseas Chinese Scholars,State Education Ministry to W.-L.Xiao.

摘　　要：Six new lignans(1-6),as well as five known ones(7-11)were isolated from the leaves and stems of Schisandra chinensis.The structures of 1-6 were established on the basis of spectroscopic methods including 1D-and 2D-NMR techniques and CD experiments.Compound 1 was the first example of naturally occurring N-containing lignans featuring a nicotinoyl group.All the new compounds were evaluated for their anti-HIV-1 activities and showed EC50 values in the range 17.89-138.23μg/mL.

关 键 词：SCHISANDRACEAE Schisandra chinensis lignan ANTI-HIV-1 

分 类 号：O62[理学—有机化学]