ANTI-HIV-1

作品数：32被引量：46H指数：4
导出分析报告
相关作者：王孝伟刘俊义郭盈刘香宜闫寒更多>>
相关机构：北京大学中国科学院更多>>
相关期刊：《Chinese Journal of Natural Medicines》《Acta Pharmacologica Sinica》《Virologica Sinica》《Natural Products and Bioprospecting》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划中国科学院知识创新工程更多>>
-
在结果中检索

检索结果分析

结果分析中...
共 条 记 录，以下是1-10
全选清除导出
参考文献引证文献引用追踪
视图：
排序：
Design and optimization of piperidinesubstituted thiophene[3,2-d]pyrimidine-based HIV-1 NNRTIs with improved drug resistance and pharmacokinetic profiles
《Acta Pharmaceutica Sinica B》2024年第7期3110-3124,共15页Yanying Sun Zhenzhen Zhou Zhongling Shi Fabao Zhao Minghui Xie Zongji Zhuo Erik De Clercq Christophe Pannecouqueb Dongwei Kang Peng Zhan Xinyong Liu 
financial support from the National Natural Science Foundation of China(NSFC Nos.81973181,82273773);Shandong Provincial Natural Science Foundation(ZR2020YQ61,ZR2020JQ31,China);Qilu Young Scholars Program of Shandong University and Taishan Scholar Program at Shandong Province.
HIV-1 reverse transcriptase(RT)has received great attention as an attractive therapeutic target for acquired immune deficiency syndrome(AIDS),but the inevitable drug resistance and side effects have always been major ...
关键词：HIV-1 NNRTIS NNIBP Structural alert Anti-HIV-1 drug candidate 
Flux Balance Analysis Reveals Potential Anti-HIV-1 Metabolic Targets
《Infectious Diseases & Immunity》2024年第2期61-68,共8页Runpeng Han Fei Luo Haisheng Yu Yajun Yan Yan Gong Conghua Xie Liang Cheng 
the National Natural Science Foundation of China(82071784);the Fundamental Research Funds for the Central Universities(2042022dx0003 and PTPP2023002);the Key Research and Development Project of Hubei Province(2020BCA069);the Translational Medicine and Interdisciplinary Research Joint Fund of Zhongnan Hospital of Wuhan University(ZNJC202007).
Background:Human immunodeficiency virus type 1(HIV-1)remains a persistent global health challenge.Therefore,a continuous exploration of novel therapeutic strategies is essential.A comprehensive understanding of how HI...
关键词：HIV-1 Flux balance analysis Genome-scale metabolic models Viral biomass objective function Therapeutic target 
Seco-cyclic phorbol derivatives and their anti-HIV-1 activities
《Chinese Journal of Natural Medicines》2024年第4期365-374,共10页HUANG Xiaolei HUANG Xusheng LI Qirun MA Mengdi CUI Yadong YANG Liumeng WANG Haibo LUO Ronghua CHEN Jinglei YANG Jingxuan LIN Jinrong LI Duxin ZHENG Yongtang ZHANG Jian 
supported by the National Natural Science Foundation of China(Nos.81202882 and 82060670);the Suzhou Science and Technology Planning Project in Jiangsu Province of China(No.SNG2021022);the Priority Academic Program Development of the Jiangsu Higher Education Institutes,China(PAPD);Project of Innovative Research Team of Yunnan Province(No.202005AE160005)。
Phorbol esters are recognized for their dual role as anti-HIV-1 agents and as activators of protein kinase C(PKC).The efficacy of phorbol esters in binding with PKC is attributed to the presence of oxygen groups at po...
关键词：seco-Cyclic phorbol derivatives Hydrolysis reaction Cyclopropane ring ESTERIFICATION Anti-HIV-1 agent 
Synthesis and anti-HIV activities of phorbol derivatives
《Chinese Journal of Natural Medicines》2024年第2期146-160,共15页HUANG Xiaolei TANG Chengrun HUANG Xusheng YANG Yun LI Qirun MA Mengdi ZHAO Lei YANG Liumeng CUI Yadong ZHANG Zhenqing ZHENG Yongtang ZHANG Jian 
supported by the National Natural Science Foundation of China(Nos.81202882,82060670);Suzhou Science and Technology Planning Project in Jiangsu Province of China(No.SNG2021022);the Priority Academic Program Development of the Jiangsu Higher Education Institutes,China(PAPD);and the Project of Innovative Research Team of Yunnan Province(No.202005AE160005).
In this study,37 derivatives of phorbol esters were synthesized and their anti-HIV-1 activities evaluated,building upon our previous synthesis of 51 phorbol derivatives.12-Para-electron-acceptor-trans-cinnamoyl-13-dec...
关键词：Phorbol esters Anti-HIV-1 activity Syncytia formation 12-(Trans-4-fluorocinnamoyl)-13-decanoyl phorbol Safety index HIV-1 entry inhibitor HIV-1 reverse transcriptase inhibitor PKC activator 
GTPase Activity of MxB Contributes to Its Nuclear Location, Interaction with Nucleoporins and Anti-HIV-1 Activity被引量：2
《Virologica Sinica》2021年第1期85-94,共10页Linlin Xie Zhao Ju Chaojie Zhong Yingjun Wu Yuxing Zan Wei Hou Yong Feng 
supported by the National Science Foundation of China(81271818 and 81471940 to YF,and 81471941,81871659 and 81828005 to WH)
The human myxovirus resistance 2(Mx2/Mx B)protein,a member of interferon(IFN)-inducible dynamin-like large GTPases,restricts a number of virus infections.Inhibition of these viruses occurs at poorly-defined steps afte...
关键词：Human immunodeficiency virus type 1(HIV-1) Human myxovirus resistance 2(MxB) GTPase activity NUCLEOPORIN Capsid(CA) Anti-viral activity 
Anti-HIV lignans from Justicia procumbens被引量：4
《Chinese Journal of Natural Medicines》2019年第12期945-952,共8页XU Xin-Ya WANG Dong-Ying KU Chuen-Fai ZHAO Yang CHENG Han LIU Kang-Lun RONG Li-Jun ZHANG Hong-Jie 
supported by the Research Grants Council of the Hong Kong Special Administrative Region,China(Nos.HKBU12103618 and HKBU12103917);the Research Grants Council of the Hong Kong Baptist University(HKBU);Interdisciplinary Research Matching Scheme(No.RC-IRMS/15-16/02);the Hong Kong Scholars Program Foundation(No.XJ2015047);Mr.Kwok Yat Wai and Madam Kwok Chung Bo Fun Graduate School Development Fund(WANG Dong-Ying)
Twenty-one lignans including three new ones(1, 2 and 13) were isolated from Justicia procumbens. The chemical structures of the new lignans were determined by spectroscopic means including 1 D and 2 D NMR analysis. Th...
关键词：Justicia procumbens Antiviral plant Lignans Anti-HIV-1 activity 
Similar pyridinone compounds with different activities of anti-HIV-1 reverse transcriptase被引量：1
《Journal of Chinese Pharmaceutical Sciences》2018年第7期469-477,共9页Yunqi Liu Xixi Li Xiaodong Dou Chao Tian Zhili Zhang Junyi Liu Xiaowei Wang 
The National Natural Science Foundation of China(Grant No.21172014,20972011 and 21042009)
Among the structurally diverse NNRTIs, pyridinone scaffolds demonstrate high potency against HIV-1 wild type and drug-resistant strains. During the optimization of our pyridinone compound 1（LAM-trans）, we found that...
关键词：Pyridinone derivatives HIV-1 Reverse transcriptase Halogen bond Molecular docking study 
The anti-HIV-1 activity of polyphenols from Phyllanthus urinaria and the pharmacokinetics and tissue distribution of its marker compound, gallic acid
《Journal of Traditional Chinese Medical Sciences》2017年第2期158-166,共9页Xiaoxue Zhang Qing Xia Guanghui Yang Dan Zhu Yanyan Shao Jiaying Zhang Yaping Cui Rufeng Wang Lanzhen Zhang 
The experiment was supported by the National Natural Science Foundation of China(30171197);Natural Science Foundation of Beijing(7073093).
Objective:To investigate the in vitro anti-HIV-1 activities and its associated mechanism of action of an extract isolated from Phyllanthus urinaria (P.urinaria) and to develop an HPLC test method for detecting gallic ...
关键词：PHYLLANTHUS urinaria ANTI-HIV-1 ACTIVITY PHARMACOKINETIC POLYPHENOL extract Gallic acid 
Design, synthesis and activity evaluation of novel pyridinone derivatives as anti-HIV-1 dual(RT/IN) inhibitors被引量：1
《Journal of Chinese Pharmaceutical Sciences》2017年第1期31-44,共14页Quanzhi Yang Tao Sheng Ningning Fan Yameng Hao Yuanyuan Cao Ying Guo Zhili Zhang Chao Tian Junyi Liu Xiaowei Wang 
National Natural Science Foundation of China(Grant No.21172014,812111023 and 81172733);grants from the Ministry of Science and Technology of China(Grant No.200 9ZX09301-010)
Three series of novel anti-immunodeficiency virus 1 （HIV-1） dual （RT/1N） inhibitors were rationally designed by introducing a functioning diketo acid （DKA） into pyridin-2-one scaffold. To efficiently analyze inh...
关键词：Pyridinone derivatives HIV-1 dual inhibitor Reverse transcriptase INTEGRASE 
Proposal and evaluation of a new norm index-based QSAR model to predict pEC50 and pCC50 activities of HEPT derivatives被引量：2
《Chinese Journal of Chemical Engineering》2016年第10期1464-1469,共6页Kanwal Shahid Qiang Wang Qingzhu Jia Lei Li Xue Cui Shuqian Xia Peisheng Ma 
Supported by the National Natural Science Foundation of China(21306137)
The search and development of anti-HIV drugs is currently one of the most urgent tasks of pharmacological studies. In this work, a quantitative structure-activity relationship （QSAR） model based on some new norm ind...
关键词：Mathematical modeling Structure-activity relationship Pharmaceuticals HEFT derivatives Anti-HIV-1 activity Prediction 
全选清除导出
共4页<1234>
检索报告 对象比较 聚类工具 使用帮助 返回顶部