NUCLEOPORIN

作品数：11被引量：27H指数：3
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相关领域：医药卫生生物学更多>>
相关机构：中国科学院大学更多>>
相关期刊：《Acta Pharmacologica Sinica》《Virologica Sinica》《World Journal of Gastroenterology》《Plant Communications》更多>>
相关基金：国家自然科学基金更多>>
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Knockdown of the nucleoporin Nup50 protects cells against ionizing radiation through enhancing DNA-PKcs-mediated DNA damage repair
《Radiation Medicine and Protection》2024年第3期194-200,共7页Zhijie Wan Jingwen Gu Songyun Zhao Hang Jia Tingting Liu Yuanyuan Chen Yanyong Yang 
supported by grants from Shanghai Rising Start Program(23QA1411600);the Hainan Provincial Natural Science Foundation of China(824QN408);Three-year Action Plan for strengthening the Construction of the public health system in Shanghai(GWVI-11.2-YQ47),China.
Objective:To investigate the effect and mechanism of Nup50 on radiation-induced DNA damage repair to radiation and explore the potential role of Nup50 as radioprotective target.Methods:The Nup50 gene was knocked down ...
关键词：damage protective P50 
Regulation of FLC nuclear import by coordinated action of the NUP62-subcomplex and importinβSAD2
《Journal of Integrative Plant Biology》2023年第9期2086-2106,共21页Gang Chen Danyun Xu Qing Liu Zhichuang Yue Biao Dai Shujuan Pan Yongqiang Chen Xinhua Feng Honghong Hu 
supported by grants from the National Natural Science Foundation(31970730 and 32170721)to H.H;the Baichuan felowship from College of Life Science and Technology,Huazhong Agricultural University to D.X。
Flowering locus C(FLC)is a central transcriptional repressor that controls flowering time.However,how FLC is imported into the nucleus is unknown.Here,we report that Arabidopsis nucleoporins 62(NUP62),NUP58,and NUP54 ...
关键词：FLC flowering time IMPORTIN nuclear import NUCLEOPORIN 
Dynamic changes in O-GlcNAcylation regulate osteoclast differentiation and bone loss via nucleoporin 153被引量：1
《Bone Research》2022年第4期799-815,共17页Yi-Nan Li Chih-Wei Chen Thuong Trinh-Minh Honglin Zhu Alexandru-Emil Matei Andrea-Hermina Györfi Frederic Kuwert Philipp Hubel Xiao Ding Cuong Tran Manh Xiaohan Xu Christoph Liebel Vladyslav Fedorchenko Ruifang Liang Kaiyue Huang Jens Pfannstiel Min-Chuan Huang Neng-Yu Lin Andreas Ramming Georg Schett Jörg H.W.Distler 
financial support provided by the following grants and institutions:Grants DI 1537/7-1, DI 1537/8-1, DI 1537/9-1, DI 1537/9-2, DI 1537/11-1,DI 1537/12-1, DI 1537/13-1, DI 1537/14-1, DI 1537/17-1, DI 1537/20-1, DI 1537/22-1,MA 9219/2-1, RA 2506/3-1 and ZH 809/2-1 of the Deutsche Forschungsgemeinschaft(DFG, German Research Foundation);SFB CRC1181 (project C01);SFB TR221/project number 324392634 (B04) and project number 52732026 of the DFG;grants J40, J82,A79 and A64 of the IZKF in Erlangen;grant 2013.056.1 of the Wilhelm-SanderFoundation;grants 2014_A47 and 2014_A184 of the Else-Kr?ner-Fresenius-Foundation;grant 14-12-17-1-Bergmann, 21-07-23-1-Gy?rfi;19-12-06-1-Matei of the ELAN-Foundation Erlangen,MASCARA program/TP2 (01EC1903A) of Federal Ministry of Education and Research (BMBF);China Scholarship Council;research Award of the German Scleroderma Foundation (Deutsche Stiftung Sklerodermie);Edith Busch Stiftung;a Career Support Award of Medicine of the Ernst Jung Foundation;Open Access funding enabled and organized by Projekt DEAL。
Bone mass is maintained by the balance between osteoclast-induced bone resorption and osteoblast-triggered bone formation.In inflammatory arthritis such as rheumatoid arthritis(RA),however,increased osteoclast differe...
关键词：OSTEOCLAST HOMEOSTASIS maintained 
GTPase Activity of MxB Contributes to Its Nuclear Location, Interaction with Nucleoporins and Anti-HIV-1 Activity被引量：2
《Virologica Sinica》2021年第1期85-94,共10页Linlin Xie Zhao Ju Chaojie Zhong Yingjun Wu Yuxing Zan Wei Hou Yong Feng 
supported by the National Science Foundation of China(81271818 and 81471940 to YF,and 81471941,81871659 and 81828005 to WH)
The human myxovirus resistance 2(Mx2/Mx B)protein,a member of interferon(IFN)-inducible dynamin-like large GTPases,restricts a number of virus infections.Inhibition of these viruses occurs at poorly-defined steps afte...
关键词：Human immunodeficiency virus type 1(HIV-1) Human myxovirus resistance 2(MxB) GTPase activity NUCLEOPORIN Capsid(CA) Anti-viral activity 
Nucleoporin 160 Regulates Flowering through Anchoring HOS1 for Destabilizing CO in Arabidopsis被引量：1
《Plant Communications》2020年第2期66-76,共11页Chunying Li Lu Liu Zhi Wei Norman Teo Lisha Shen Hao Yu 
This work was supported by the Singapore National Research Foundation Investigatorship Program(NRF-NRFI2016-02);the intramural research support from National University of Singapore and Temasek Life Sciences Laboratory.
Nuclear pore complexes(NPCs),which comprise multiple copies of nucleoporins(Nups),are large protein assemblies embedded in the nuclear envelope connecting the nucleus and cytoplasm.Although it has been known that Nups...
关键词：nuclear pore complexes HOS1 CO flowering time 
Post-translational O-GlcNAcylation is essential for nuclear pore integrity and maintenance of the pore selectivity filter被引量：1
《Journal of Molecular Cell Biology》2016年第1期2-16,共15页Yanping Zhu Ta-Wei Liu Zarina Madden Scott A.Yuzwa Kelsey Murray Samy Cecioni Natasha Zachara David J.Vocadlo 
supported by a Discovery Grant(grant no.RGPIN/298406-2010)fromthe Natural Sciences and Engineering Research(NSERC),and the Canadian Institutes of Health Research(CIHR)(grant no.MOP-123341).Y.Z.thanks the CIHR for support through a postdoctoral fellowship.D.J.V.acknowledges the kind support of the Canada Research Chairs Program for a Tier I Canada Research Chair in Chemical Glycobiology and NSERC for support as an E.W.R.Steacie Memorial Fellow.N.Z.acknowledges the support from the National Heart Lung and Blood Institute(P01HL107153).
O-glycosylation of the nuclear pore complex(NPC)by O-linked N-acetylglucosamine(O-GlcNAc)is conserved within metazoans.Many nucleoporins(Nups)comprising the NPC are constitutively O-GlcNAcylated,but the functional rol...
关键词：post-translational modification O-GLCNACYLATION nuclear pore complex protein stability UBIQUITINATION NUCLEOPORIN GLYCOSYLATION 
Nucleoporin 35 regulates cardiomyocyte pH homeostasis by controlling Na^(+)-H^(+)exchanger-1 expression
《Journal of Molecular Cell Biology》2015年第5期476-485,共10页Liang Xu Lei Pan Jun Li Bijun Huang Jing Feng Changming Li ShiyiWang Erlinda The Yuan Liu Tianyou Yuan Lixiao Zhen Dandan Liang Yi Liu Li Li Yingyu Cui Xiaoyan Jiang Luying Peng Yi-Han Chen 
This work was supported by grants from the National Key Basic Research Program of China(2013CB531100 to Y.-H.C.);the National Natural Science Foundation of China for National Innovative Research Groups(81221001 to Y.-H.C.);the Major International Joint Research Program of China(81120108004 to Y.-H.C.);the Youth Program(81100124 to L.X.);the General Program(81170224 and 81270313 to J.L.and 31271214 to Y.-H.C.)of the National Natural Science Foundation of China.
The mammalian nuclear pore complex is comprised of∼30 different nucleoporins(Nups).It governs the nuclear import of gene expression modulators and the export of mRNAs.In cardiomyocytes,Na1-H1 exchanger-1(NHE1)is an i...
关键词：CARDIOMYOCYTE intracellular pH Na^(+)-H^(+)exchanger nuclear pore complex nucleo-cytoplasmic transport 
New targets for the antitumor activity of gambogic acid in hematologic malignancies被引量：8
《Acta Pharmacologica Sinica》2013年第2期191-198,共8页Li-jing YANG Yan CHEN 
Gambogic acid （GA） is the main active ingredient of gamboge, a brownish to orange dry resin secreted from Garcinia hanburyi, a plant that is widely distributed in nature. Recent in vitro and in vivo studies have dem...
关键词：gambogic acid hematological malignancies death inducer-obliterator HERG channel NUCLEOPHOSMIN NUCLEOPORIN steroidreceptor coactivator-3 reactive oxygen species 
Effects of Gambogic Acid on the Regulation of Nucleoporin Nup88 in U937 Cells被引量：3
《Journal of Huazhong University of Science and Technology(Medical Sciences)》2007年第4期388-392,共5页舒文秀 陈燕 何静 崔国惠 
This project was supported by a grant from the National Natural Sciences Foundation of China (No 30472267)
In order to investigate the anti-leukemia effects of gambogic acid （GA） and its relation to the regulation of nucleoporin Nup88 in U937 cells in vitro, the inhibitory effect of GA on the growth of U937 cells was exa...
关键词：gambogic acid acute leukemia APOPTOSIS NUP88 
Nucleoporin 88 expression in hepatitis B and C virus-related liver diseases被引量：4
《World Journal of Gastroenterology》2006年第36期5870-5874,共5页Martina Knoess Anna Kordelia Kurz Olga Goreva Nuran Bektas Kai Breuhahn Magarethe Odenthal Peter Schirmacher Hans Peter Dienes C Thomas Bock Hanswalter Zentgraf Axel zur Hausen 
AIM: To investigate the expression of nucleoporin 88 (Nup88) in hepatitis B virus (HBV) and C virus (HCV)-related liver diseases. METHODS: We generated a new monoclonal Nup88 antibody to investigate the Nup88 protein ...
关键词：Nucleoporin 88 Hepatitis B and C virus Hepatocellular carcinogenesis 
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