New targets for the antitumor activity of gambogic acid in hematologic malignancies  

作　　者：Li-jing YANG Yan CHEN 

机构地区：[1]Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan430022, China

出　　处：《Acta Pharmacologica Sinica》2013年第2期191-198,共8页中国药理学报（英文版）

摘　　要：Gambogic acid （GA） is the main active ingredient of gamboge, a brownish to orange dry resin secreted from Garcinia hanburyi, a plant that is widely distributed in nature. Recent in vitro and in vivo studies have demonstrated that GA exerts potent antitumor effects against solid tumors of various derivations, and its antitumor mechanisms have been thoroughly investigated. On the other hand, normal cells remain relatively resistant to GA, indicating a therapeutic window. GA is currently in clinical trials in China. Over the last decade, our laboratory demonstrates that GA exhibits potent anticancer activities against hematological malignancies. This review focuses on the new mechanisms through which GA inhibits proliferation and induces apoptosis in malignant hematological cells. These include the regulation of expression and intracellular positioning of nucleoporin and nucleophosmin; downregulation of steroid receptor coactivator-3 （SRC-3） and its downstream proteins; upregulation of death inducer-obliterator （DIO-1）; downregulation of HERG potassium channel; as well as induction of reactive oxygen species （ROS） accumulation.Gambogic acid （GA） is the main active ingredient of gamboge, a brownish to orange dry resin secreted from Garcinia hanburyi, a plant that is widely distributed in nature. Recent in vitro and in vivo studies have demonstrated that GA exerts potent antitumor effects against solid tumors of various derivations, and its antitumor mechanisms have been thoroughly investigated. On the other hand, normal cells remain relatively resistant to GA, indicating a therapeutic window. GA is currently in clinical trials in China. Over the last decade, our laboratory demonstrates that GA exhibits potent anticancer activities against hematological malignancies. This review focuses on the new mechanisms through which GA inhibits proliferation and induces apoptosis in malignant hematological cells. These include the regulation of expression and intracellular positioning of nucleoporin and nucleophosmin; downregulation of steroid receptor coactivator-3 （SRC-3） and its downstream proteins; upregulation of death inducer-obliterator （DIO-1）; downregulation of HERG potassium channel; as well as induction of reactive oxygen species （ROS） accumulation.

关 键 词：gambogic acid hematological malignancies death inducer-obliterator HERG channel NUCLEOPHOSMIN NUCLEOPORIN steroidreceptor coactivator-3 reactive oxygen species 

分 类 号：Q64[生物学—生物物理学] TQ463.5[化学工程—制药化工]