Asymmetric Hydrogenation of 2-Aryl-5,6-dihydropyrazine Derivatives with Chiral Cationic Ruthenium Diamine Catalysts  

作　　者：Yong Li Yanmei He Fei Chen Qinghua Fan 

机构地区：[1]Beijing National Laboratory for Molecular Sciences,CAS Key Laboratory of Molecular Recognition and Function,Institute of Chemistry,Chinese Academy of Sciences(CAS),Beijing 100190,China [2]Department of Chemistry,Henan Institute of Education,Zhengzhou,Henan 450046,China [3]Collaborative Innovation Center of Chemical Science and Engineering,Tianjin,China

出　　处：《Chinese Journal of Chemistry》2014年第10期991-994,共4页中国化学（英文版）

基　　金：We thank the National Natural Science Foundation of China(Grant No.21232008);National Basic Research Program of China(973 Program,2010CB-833300),Foundation for University Youth Key Teacher of Henan Province(2013GGJS-207)and the Chinese Academy of Sciences(CMS-PY-201303)for financial supports.

摘　　要：The first asymmetric hydrogenation of unfunctionalized 2-substituted and 2,3-disubstituted 5,6-dihydropyrazines catalyzed by chiral cationic Ru-diamine complex(R,R)-1a was developed,affording chiral piperazine derivatives with good enantioselectivities(up to 89% ee).

关 键 词：asymmetric hydrogenation RUTHENIUM chiral diamines PIPERAZINES 

分 类 号：O62[理学—有机化学]