the financial support from the National Natural Science Foundation of China(22001121);Nanjing Tech University。
A catalyst-free and additive-free ring-opening reaction of polyfluoroalkyl peroxides,triethylenediamine(DABCO),and 1,2-dichloroethane(DCE)has been developed for the defluorinative synthesis of structurally diverse pip...
A series of N,N-disubstituted piperazines were synthesized containing the structural elements of both methylenedioxybenzylpiperazine (MDBP) and trifluoromethylphenylpiperazine (TFMPP)in a single molecule.These six pot...
We thank the National Natural Science Foundation of China(Grant No.21232008);National Basic Research Program of China(973 Program,2010CB-833300),Foundation for University Youth Key Teacher of Henan Province(2013GGJS-207)and the Chinese Academy of Sciences(CMS-PY-201303)for financial supports.
The first asymmetric hydrogenation of unfunctionalized 2-substituted and 2,3-disubstituted 5,6-dihydropyrazines catalyzed by chiral cationic Ru-diamine complex(R,R)-1a was developed,affording chiral piperazine derivat...
Oxidations of piperazine, 1-methylpiperazine and 1-ethylpiperazine by bromamine-T (BAT) in buffered acidic medium have been kinetically studied at 303 K. The reaction shows a first-order dependence of the rate each on...
An interesting approach for the design of anti-allergies is rationally considered. It was proved that current anti-allergic drugs comprise piperazine and acrylic acid segments. In harmony with these findings, new prod...