Asymmetric Pudovik Reaction of Chiral Fluoroalkyl α,β-Unsaturated Ketimines and Diphenyl Phosphite  

作　　者：Peng Li Min Jiang Jin-Tao Liu 

机构地区：[1]Key Laboratory of Organofluorine Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China

出　　处：《Chinese Journal of Chemistry》2014年第10期1003-1006,共4页中国化学（英文版）

基　　金：Financial support from the National Natural Science Foundation of China(No.21172243)is gratefully acknowledged.

摘　　要：The asymmetric Pudovik reaction of chiral fluoroalkyl α,β-unsaturated ketimines derivated from(R)-tert-butanesulfinamide and diphenyl phosphite was achieved in the presence of Rb2CO3 at room temperature.A series of fluoroalkylated α-amino phosphonates were prepared in good yields with high diastereoselectivities.

关 键 词：diphenyl phosphite HYDROPHOSPHONYLATION N-tert-butanesulfinyl ketimine diastereoselectivity Pudovik reaction 

分 类 号：O62[理学—有机化学]