Supramolecular Nanofibers/Hydrogels of the Conjugates of Nucleobase,Saccharide,and Amino Acids  

作　　者：Dongdong Wu Xuewen Du Junfeng Shi Jie Zhou Bing Xu 

机构地区：[1]Department of Chemistry,Brandeis University,415 South St.,Waltham,MA 02454,USA

出　　处：《Chinese Journal of Chemistry》2014年第4期313-318,共6页中国化学（英文版）

基　　金：This work was supported by National Institutes of Health(No.NIH R01CA142746).

摘　　要：Three new hydrogelators based on the conjugates of three naturally occurring biological building blocks:nu-cleobase,saccharide,and amino acids,were explored.Being synthesized via a facile solid phase peptide synthesis route,the hydrogelators self-assemble in water to afford supramolecular nanofibers and hydrogels.Transmission electron microscopy,oscillation rheometry,and circular dichroism reveal that the hydrogels consist of largely he-lix-based nanofibers of the widths of 5-12 nm and exhibit storage moduli up to 1 kPa.These hydrogelators also exhibit excellent cell-compatibility.This work illustrates a new platform for constructing molecular soft materials for nanobiotechnology.

关 键 词：HYDROGELATOR NUCLEOSIDE peptide nanofiber 

分 类 号：O62[理学—有机化学]