水凝胶在肿瘤放射治疗中的间隔与保护作用研究进展  

Research progress in the spacing and protection of hydrogels in radiotherapy for tumors

作　　者：黄晓敏 刘芳 谢利娟 Huang Xiaomin;Liu Fang;Xie Lijuan(Beijing Leadingpharm Medicine Technology Development Co.,Ltd.,Beijing 100080,China)

机构地区：[1]北京新领先医药科技发展有限公司,北京100080

出　　处：《中华放射医学与防护杂志》2023年第8期657-662,共6页Chinese Journal of Radiological Medicine and Protection

摘　　要：放射治疗是肿瘤治疗的主要方法之一,但周围的健康组织由于也受到一定剂量的照射,可能造成放射性损伤,甚至个别患者程度较为严重。可注射的水凝胶有望通过将邻近器官与肿瘤部位实现“间隔(Spacing)”,提高靶区的放射剂量,降低放疗期间周围健康组织和器官受到辐射损伤的风险,从而提高患者的生存质量,是降低放疗相关不良反应潜在的有效治疗策略。本文对水凝胶在不同肿瘤放射治疗中发挥间隔和保护作用的最新进展进行综述。Radiotherapy is a primary method for treating tumors.However,since surrounding healthy tissues may also receive a certain dose of irradiation during the radiotherapy,they may suffer from radiation-induced damage,which is even serious for certain patients.Injectable hydrogels are expected to achieve the spacing between target areas and their surrounding tissues during radiotherapy,thus increasing the dose to the target areas while reducing the risk of radiation-induced damage to surrounding healthy tissues and organs.Accordingly,the quality of life of the patients can be improved.Therefore,applying injectable hydrogels serves as a potential strategy for reducing the adverse reactions associated with radiotherapy.This paper reviews the latest research progress in the spacing and protection of hydrogels in radiotherapy for different tumors.

关 键 词：水凝胶 放射治疗 间隔 肿瘤 

分 类 号：R730.55[医药卫生—肿瘤]