原发中枢神经系统淋巴瘤的临床、影像学特征分析  

Analysis of clinical,imaging features of primary central nervous system lymphoma

作　　者：崔博 丁岩[1] 卫华[1] 朴月善[2] 杨西西 李存江[1] Cui Bo;Ding Yan;Wei Hua;Piao Yueshan;Yang Xixi;Li Cunjiang(Department of Neurology,Xuanwu Hospital,Capital Medical University,Beijing 100053,China)

机构地区：[1]首都医科大学宣武医院神经内科,北京100053 [2]首都医科大学宣武医院病理科,北京100053

出　　处：《北京医学》2023年第5期432-435,共4页Beijing Medical Journal

摘　　要：目的探讨原发中枢神经系统淋巴瘤(primary central nervous system lymphoma,PCNSL)的临床与影像学特点。方法回顾性分析首都医科大学宣武医院收治的1例病理确诊的PCNSL患者的临床资料、影像学、神经病理及后续治疗效果等资料。结果本例患者因“进行性头痛6个月、视物变形1个月”就诊,临床查体提示左下肢轻瘫,影像学表现为右侧半球占位性病变,病灶随时间逐渐进展,经立体定向活检证实为弥漫大B细胞淋巴瘤,后转入血液科行R2-MTX方案化疗,3个月后临床症状与影像学病灶均得到改善。结论尽早脑活检、甚至必要时重复活检,有助于明确PCNSL诊断。早期规范化治疗有助于PCNSL患者获益。Objective To explore the clinical and imaging features of primary central nervous system lymphoma(PCNSL).Methods The clinical data,imaging,neuropathology and follow-up treatment effect of a pathologically diagnosed patient with PCNSL in Xuanwu Hospital,Capital Medical University was analyzed.Results The patient was treated for"progressive headache for six months and visual distortion for one month".The clinical physical examination showed paraplegia of the left lower extremity,and the imaging manifestations were space occupying lesions in the right hemisphere.The lesions gradually progressed with time,and were confirmed as diffuse large B-cell lymphoma by stereotactic biopsy,and then transferred to Hematology Department for R2-MTX chemotherapy.The clinical symptoms and imaging lesions were improved after three months.Conclusions Brain biopsy as early as possible or even repeated biopsy when necessary is helpful to make a definite diagnosis of PCNSL.Early standardized treatment benefits PCNSL patients.

关 键 词：原发中枢神经系统淋巴瘤 立体定向活检 占位性病变 

分 类 号：R739.4[医药卫生—肿瘤]