食管鳞状细胞癌脑转移危险因素分析  

Analysis of risk factors for brain metastasis in patients with esophageal squamous cell carcinoma

作　　者：陈培楠 韩文莉[2] 白合林 宋昕 赵学科[2] 乔佳欣[2] 韩雪娜 范宗民[2] 王苒[2] 李贝[2] 罗宏[3] 黄炳文 王立东 CHEN Peinan;HAN Wenli;BAI Helin;SONG Xin;ZHAO Xueke;QIAO Jiaxin;HAN Xuena;FAN Zongmin;WANG Ran;LI Bei;LUO Hong;HUANG Bingwen;WANG Lidong(Department of Thoracic Surgery,the Affiliated Cancer Hospital,Zhengzhou University,Henan Cancer Hospital,Zhengzhou 450008;State Key Laboratory of Esophageal Cancer Prevention&Treatment and Henan Key Laboratory for Esophageal Cancer Research,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052;Guangshan County People′s Hospital,Xinyang,Henan 465499)

机构地区：[1]郑州大学附属肿瘤医院(河南省肿瘤医院)胸外科,郑州450008 [2]郑州大学第一附属医院省部共建食管癌防治国家重点实验室,郑州450052 [3]光山县人民医院,河南信阳465499

出　　处：《郑州大学学报（医学版）》2023年第5期610-613,共4页Journal of Zhengzhou University(Medical Sciences)

基　　金：国家自然科学基金面上项目(81872032);河南省医学科技攻关计划项目(LHGJ20210197);河南省肿瘤医院博士启动资金资助项目(1186)。

摘　　要：目的:探讨食管鳞状细胞癌(食管鳞癌)脑转移的危险因素。方法:回顾性分析来自省部共建食管癌防治国家重点实验室食管/贲门癌临床诊疗、病理和随访信息数据库中46例食管癌脑转移术后患者的资料,采用倾向性评分匹配法选取46例未发生脑转移的食管鳞癌患者;比较两组的临床病理特征,使用条件Logistic回归分析筛选食管鳞癌脑转移的危险因素。结果:与非脑转移组比较,食管鳞癌脑转移组低分化患者比例较大,淋巴结转移阳性率较高(P<0.05)。条件Logistic回归分析结果显示,淋巴结转移阳性是食管鳞癌脑转移的危险因素,OR(95%CI)为11.086(1.286~95.557)。结论:淋巴结转移阳性是食管鳞癌脑转移的危险因素。Aim:To explore the risk factors of brain metastasis in esophageal squamous cell carcinoma(ESCC).Methods :Retrospective analysis was made on 46 ESCC patients with brain metastasis after ESCC surgery from the database established by the State Key Laboratory of Esophageal Cancer Prevention and Treatment,which included the clinical treatment,pathological diagnosis and follow-up information of esophagus and gastric cardia cancers.Totally 46 ESCC patients without brain metastasis were selected as control using propensity score matching method.The clinicopathological characteristics between the 2 groups were compared,and conditional Logistic regression analysis was used to screen risk factors for brain metastasis of ESCC. Results :Compared with the non-brain metastasis group,the proportion of poorly differentiated patients and the positive rate of lymph node metastasis in the brain metastasis group were higher( P <0.05). The results of conditional Logistic regression analysis showed that lymph node metastasis was a risk factor for brain metastasis,with OR(95%CI) of 11.086(1.286-95.557). Conclusion :Lymph node metastasis may be a risk factor for brain metastasis of ESCC.

关 键 词：食管鳞状细胞癌 脑转移 临床病理特征 危险因素 

分 类 号：R735.1[医药卫生—肿瘤]