不同年龄分层下内脏脂肪指数与认知能力障碍的相关性研究  

Analysis of correlation between visceral adiposity index and cognitive impairment by age stratification

作　　者：方堃 潘小民[2] 刘江[2] 魏挺[2] 赵蓓玉 屈秋民[3] 霍康[3] FANG Kun;PAN Xiaomin;LIU Jiang;WEI Ting;ZHAO Beiyu;QU Qiumin;HUO Kang(Department of Nephrology,the First Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710061;Department of Internal Medicine,the Hospital of Xi’an Jiaotong University,Xi’an 710049;Department of Neurology,the First Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710061,China)

机构地区：[1]西安交通大学第一附属医院肾内科,陕西西安710061 [2]西安交通大学医院内科,陕西西安710049 [3]西安交通大学第一附属医院神经内科,陕西西安710061

出　　处：《南京医科大学学报（自然科学版）》2023年第9期1216-1222,共7页Journal of Nanjing Medical University(Natural Sciences)

基　　金：国家自然科学基金(82201580);陕西省自然科学基金(2023-JC-YB-736)。

摘　　要：目的:探讨中国内脏脂肪指数(Chinese visceral adiposity index,CVAI)与认知能力障碍(cognitive impairment,CI)的相关性,并进一步分析不同年龄分层下两者的相关性,为准确评估两者关系,提供新的可干预的认知功能影响因素提供依据。方法:选取CHARLS数据库2011年和2015年的数据,包括研究对象的性别、年龄、教育程度、饮酒、吸烟史以及体重指数和生化指标。应用Logistic回归分析CVAI与CI的相关性,并根据不同年龄进行分层分析。结果:①在12102例研究对象中,认知能力障碍者为1295例(10.7%);②在≥65岁人群中,CVAI与CI具有相关性(P<0.05),而在<65岁人群中CVAI与CI无明显相关性;③利用截断值(161.94),所有研究对象可分为高CVAI组(CVAI≥161.94)和低CVAI组(CVAI<161.94);④年龄与CI呈正相关(OR=2.24,95%CI:1.66~3.03),教育程度与CI呈负相关(OR=0.71,95%CI:0.53~0.94),在≥65岁人群中,高CVAI与CI呈正相关(OR=1.91,95%CI:1.24~2.93)。结论:CVAI、年龄、教育程度均与CI相关。在65岁及以上人群,高CVAI是CI的危险因素。Objective:The current study aims to explore the correlation between Chinese visceral adiposity index(CVAI)and cognitive impairment(CI),and further to analyze the correlation between CVAI and CI under different age levels,providing evidence for accurately evaluating the relationship between CVAI and CI,and seeking for new factors available for intervention associated with CI.Methods:The CHARLS database was used in the current study.The baseline data of 2011 and 2015 were collected,including gender,age,education level,alcohol consumption,smoking history,body mass index,and biochemical indicators.Logistic regression analysis was used to analyze the correlation of CVAI and CI,according to difterent age stratification.Results:①A total of 12102 subjects were included in the curreut study,1295(10.7%)subjects had CI.②There was a correlation between CVAI and CI in people aged 65 and above(P<0.05),but no significant correlation between CVAI and CI in people aged below 65(P>0.05);③The best cut⁃off value of CVAI for CI was 161.94.According to the cut⁃off value,all subjects was divided into high CVAI group(CVAI≥161.94)and low CVAI group(CVAI<161.94).④Age was positively correlated with CI(OR=2.24,95%CI:1.66-3.03),education level was negatively correlated with CI(OR=0.71,95%CI:0.53-0.94),and high CVAI was correlated with CI in people aged 65 and above(OR=1.91,95%CI:1.24-2.93).Conclusion:CVAI,age and education were correlated with CI.High CVAI is a risk factor for CI in people 65 years and older.

关 键 词：内脏脂肪指数 肥胖 认知障碍 

分 类 号：R749.1[医药卫生—神经病学与精神病学]