不同修复材料对前牙PFM修复患者GCF中炎症、破骨细胞调节因子的影响  

Effects of Different Restoration Materials on Inflammation and Osteoclastic Cytokines of GCF in Anterior Teeth PFM Restoration Patients

作　　者：马庆云[1] 李会斌 段风[1] 张文涛 MA Qing-yun;LI Hui-bin;DUAN Feng(Department of Stomatology,the Second Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang Shaanxi 712000)

机构地区：[1]陕西中医药大学第二附属医院口腔科,陕西咸阳712000 [2]咸阳市秦都区小白兔口腔门诊部,陕西咸阳712000 [3]西安高新医院口腔科,陕西西安710075

出　　处：《医学临床研究》2023年第8期1172-1175,共4页Journal of Clinical Research

摘　　要：【目的】探讨不同修复材料对前牙烤瓷熔附金属全冠(PFM)修复患者龈沟液(GCF)中炎症因子、破骨细胞调节因子的影响。【方法】选择陕西中医药大学第二附属医院2019年6月至2022年6月收治的180例前牙PFM修复患者,按照随机数字表法分为A组(使用镍铬合金材料修复)、B组(使用钴铬合金材料修复)、C组(使用金沉积材料修复),每组60例。比较三组患者修复前后牙龈情况、GCF中炎症因子水平和破骨细胞调节因子水平以及修复体完整率。【结果】修复后,三组GCF量、龈沟探诊深度(GCD)均高于修复前,牙龈指数(GI)评分低于修复前(P<0.05);修复后,A组上述指标高于B组、C组(P<0.05),但B组、C组上述指标比较,差异无统计学意义(P>0.05)。修复后,三组GCF中炎症因子水平均高于修复前(P<0.05);修复后,A组GCF炎症因子水平高于B组、C组(P<0.05),但B组、C组比较,差异无统计学意义(P>0.05)。修复后,三组细胞核因子κB受体活化因子配体(RANKL)水平、RANKL/骨保护素(OPG)均高于修复前,OPG低于修复前(P<0.05);修复后,A组RANKL、RANKL/骨保护素(OPG)高于B组、C组,OPG低于B组、C组(P<0.05),但B组、C组上述指标比较,差异无统计学意义(P>0.05);三组修复体完整率比较,差异无统计学意义(P>0.05)。【结论】与镍铬合金材料修复相比,PFM修复中使用钴铬合金材料修复、金沉积材料修复患者炎症因子水平更低,对破骨细胞的影响更小,生物相容性与修复后的牙体稳定性更高,推荐临床选择。【Objective】To compare the effects of different restoration materials on inflammation and osteoclastic cytokines in gingival sulcus fluid(GCF)in patients with anterior tooth porcelain fused metal(PFM)full crown restoration.【Methods】A total of 180 patients with anterior tooth PFM restoration admitted to the Second Affiliated Hospital of Shaanxi University of Chinese Medicine from June 2019 to June 2022 were randomly divided into three groups:Group A(n=60),Group B(n=60),and Group C(n=60).Group A was remediated using nickel-chromium materials,Group B was remediated using cobalt-chromium materials,and Group C was remediated using gold deposited materials.The gum condition,GCF inflammatory factor level,GCF osteoclastic regulator level and restoration integrity rate before and after repair were compared between the three groups.【Results】After restoration,the GCF volume and gingival groove exploration depth(GCD)were higher than those before restoration,while the gingival index(GI)was lower than that before restoration(P<0.05).After restoration,the above indexes in group A were higher than those in groups B and C(P<0.05),but there was no significant difference between group B and group C(P>0.05).Levels of inflammatory factors in GCF of the three groups after restoration were higher than those before restoration(P<0.05);And the GCF inflammatory factor levels in group A after restoration were higher than those in groups B and C(P<0.05),but the comparison between group B and group C was not significant(P>0.05).The levels of RANKL(receptor activator of nuclear factorκB ligand)and RANKL/OPG(osteoprotegerin)in the three groups after restoration were higher than those before restoration,while the OPG was lower than that before restoration(P<0.05).After restoration,the nuclear factorκB receptor activating factor ligand(RANKL)and RANKL/osteoprotectin(OPG)in group A were higher than those in groups B and C,and its OPG was lower than that in the group B and group C(P<0.05).However,there was no significant difference of

关 键 词：牙科材料 金属烤瓷合金 牙龈缝液 RANK配体 

分 类 号：R781.4[医药卫生—口腔医学]