磁小体在肿瘤治疗中的应用研究进展  

Research progress on the application of bacterial magnetic particles in tumor therapy

作　　者：杜盼 戚金风 潘贤儒 王金霞[1] 张薇薇[1] DU Pan;QI Jinfeng;PAN Xianru;WANG Jinxia;ZHANG Weiwei(The First Clinical Medical College,Gansu University of Chinese Medicine,Lanzhou,Gansu,730101,China)

机构地区：[1]甘肃中医药大学第一临床医学院,甘肃兰州730101

出　　处：《甘肃中医药大学学报》2023年第4期75-79,共5页Journal of Gansu University of Chinese Medicine

基　　金：甘肃中医药大学引进人才科研启动基金项目(2016YJRC-02);甘肃省卫生行业科研计划项目(GSWSKY2016-25);2021年甘肃中医药大学第一临床医学院本科生科研及创新创业项目(第一临床院发〔2021〕55号);2022年甘肃中医药大学第一临床医学院创新创业教育项目(第一临床院发〔2022〕14号);甘肃中医药大学2022年大学生创新创业训练计划项目(甘中医大创发〔2022〕7号)。

摘　　要：查阅文献,对磁小体在肿瘤治疗中的应用研究进展进行概述。磁小体具有超顺磁性、低细胞毒性及良好的分散性和生物相容性,并具有足够的空间分辨率和高灵敏度,且易于功能化修饰,其作为抗肿瘤药物的良好载体及造影剂,可在肿瘤磁流体热疗、免疫治疗、基因治疗、光热-化学动力学联合治疗以及分子成像、可视化疗法中发挥重要作用,有望成为构建可视化肿瘤诊疗一体化平台的磁性纳米材料。目前研究中还存在大量问题亟待解决,今后应进行深入研究,将磁小体这一优势载体更好地应用于肿瘤的临床治疗中,以提高肿瘤患者的疗效。By reviewing the literature,this paper overviews the research progress of the application of bacterial magnetic particles(BMPs)in tumor therapy.BMPs has the advantages of superparamagnetism,low cytotoxicity,good dispersivity and biocompatibility,and has sufficient spatial resolution and high sensitivity,and is easy to be functionalized.As a good carrier and contrast agent of anti-tumor drugs,it can play an important role in tumor magnetic fluid hyperthermia,immunotherapy,gene therapy,photothermal and chemical kinetics combined therapy,molecular imaging,and visualization therapy.It is expected to become a magnetic nanomaterial for building a visual integrated platform for tumor diagnosis and treatment.At present,there are still a lot of problems to be solved in the research.In the future,more in-depth researches should be carried out.As the dominant carrier,BMPs will be better applied in the clinical treatment of tumors to improve the curative effect of tumor treatment.

关 键 词：磁小体 治疗 诊断 分子成像 可视化疗法 综述 

分 类 号：R73-354[医药卫生—肿瘤] R318.08[医药卫生—临床医学]