基于“脾虚-内质网应激”探讨健脾法对炎症性肠病肠纤维化内质网应激的调节作用  

Research of regulatory effect of spleen-strengthening therapy on endoplasmic reticulum stress in inflammatory bowel disease with intestinal fibrosis based on“spleen deficiency and endoplasmic reticulum stress”theory

作　　者：杜林柯 郑烈 段盛蕾 Lin-Ke Du;Lie Zheng;Sheng-Lei Duan(Shaanxi Provincial Hospital of Traditional Chinese Medicine,Xi'an 710003,Shaanxi Province,China)

机构地区：[1]陕西省中医医院,陕西省西安市710003

出　　处：《世界华人消化杂志》2023年第16期666-670,共5页World Chinese Journal of Digestology

基　　金：西安市科技局计划项目,No.2023JH-YXYB-0197;陕西省中医医院“苗圃培优”计划项目,No.2021-07,陕西省自然科学基础研究计划一般项目,No.2019JM-580(面上);陕西省中医药管理局科研项目,No.2019-ZZ-JC010;陕西省中医医院院级课题,No.2018-04和No.2021-07.

摘　　要：肠纤维化是炎症性肠病(inflammatory bowel disease,IBD)常见并发症之一,内质网应激参与纤维化形成是其重要发病机制.内质网是细胞内最大的膜网络结构,主要参与机体蛋白质的合成代谢.脾主运化是脾脏正常的生理功能,脾虚不能运化水谷精微,导致湿热、痰浊、瘀毒等病理产物壅滞于肠道,肠壁增厚,甚至肠腔狭窄、梗阻,诱发本病.生理学上,脾和内质网有一定相关性;病理学上,脾虚是内质网应激的本质,是IBD肠纤维化的核心病理环节.因此,从健脾法治疗有助于改善内质网代谢功能.所以,基于“脾虚-内质网应激”理论探讨健脾法调节内质网应激、恢复内质网稳态是研究和治疗IBD肠纤维化作用机制的重要理论.Intestinal fibrosis is one of the common complications of inflammatory bowel disease(IBD),and endoplasmic reticulum(ER)stress plays an important role in the pathogenesis of fibrosis.The ER is the largest membrane network structure in the cell,which is mainly involved in the anabolism of proteins.Governing transportation and transformation is the normal physiological function of the spleen,and spleen deficiency leads to the failure of transporting the fine water and valley,resulting in dampness-heat,phlegm turbidness,blood stasis and other pathological products obstructed in the intestine,intestinal wall thickening,and even intestinal cavity stenosis and obstruction,thus inducing the development of IBD.Physiologically,the spleen and ER have a certain correlation.Pathologically,spleen deficiency is the essence of ER stress and the core pathological link of IBD intestinal fibrosis.Therefore,spleen-strengthening therapy is helpful to improve the metabolic function of the ER.Exploring the regulation of ER stress and restoration of ER homeostasis by spleen-strengthening therapy based on the“spleen deficiency-ER stress”theory is of great significance for studying and treating IBD intestinal fibrosis.

关 键 词：“脾虚-内质网应激” 健脾法 炎症性肠病 肠纤维化 

分 类 号：R574[医药卫生—消化系统]